Fig. 2. Effect of AAV-α-synuclein and/or FN075 on human α-synuclein staining in the rat nigrostriatal pathway. Although unilateral administration of AAV-α-synuclein induced significant α-synuclein overexpression in the (a) substantia nigra and (b) striatum, this was unaffected by subsequent FN075 administration. Data are represented as mean ± SEM with n = 10 animals per group. ** p< 0.01, *** p < 0.001, **** p< 0.0001 vs. Control by one-way ANOVA with post hocTukey.