Animals & Ethical Statement
Forty adult female Sprague-Dawley rats (Charles River, Margate, UK) were used in this research. All procedures involving the use of animals were completed in accordance with the European Union Directive 2010/63/EU and the Irish Statutory Instrument S.I. No. 543 of 2012; were sanctioned by the Animal Care and Research Ethics Committee (ACREC) of the University of Galway; and were carried out under Project and Individual Authorisations issued by the Irish Health Products Regulatory Authority. Animals were pair housed, on a 12:12 light:dark cycle, with 19-23 ◦C temperature and 40-70% humidity. Water and food were provided ad libitum over the course of the experiments except for 24 h before the Corridor Test was performed in which their food ration was restricted (to ensure they were driven to perform this food-motivated test). All behavioural testing and post-mortem analyses were completed by a researcher blinded to the treatment of the rats.