Figure Legends:
Legend to Fig 1
Simultaneous computation of biplane left atrial volume and strain (reservoir, conduit and booster strain) using the 2D strain software on images sampled at >60 Hz. Data obtained using the 3-click method (the 2 basal segments and at the roof of the atrium)
Legend to Fig 2
Application of indices of myocardial work in different phenotypes and grades of aortic stenosis (AS). Left panel: Low flow low gradient phenotype of severe AS with poor GWE, very low LV-GLS, and very high global wasted work, necessitating emergent referral for valve replacement. In comparison, a patient with moderate AS with preserved global work efficiency (GWE) (upper right) may have a delayed follow up while the patient in the lower right panel with reduced global wasted work (GWW), would require a follow up echo sooner than the one with preserved GWE.
Legend to Fig 3
Aortic valve area estimation using indices of myocardial work. Parameters included in the model are LVEF%, LV-GLS%, global work efficiency (GWE), global wasted work (GWW), global work index (GWI), and global constructive work (GCW). Significant p-values are in red.
Legend to Fig 4
Left ventricular longitudinal strain with apical sparing pattern in cardiac amyloidosis. The photo collage has been created just by 3- clicking the apical 3-chamber cine-loops. The AI based software searches the 2 other apical loops to compute the Bull´s eye with” cherry on the top” without any more human aid on the 2D spacetime with the LV in motion.
Legend to Fig 5
Myocardial work efficiency and the apical sparing strain: the differing pressure strain loops in different apical segments (the green pressure strain loops in panels B, C, and D) may suggest that the preserved apical strain may not be homogeneously distributed. Fig A is the global pressure strain loop in red. Bar diagrams: the green represents constructive work; blue represents wasted work. Pathophysiological significance of such heterogeneity is currently unknown.
Legend to Figures 6.
A patient with sigmoid type hypertrophic cardiomyopathy. On the right side a Bull´s eye plot, created by tracking 3 apical loops, shows regional strain gradients. On the left side myocardial work index showing a distorted and truncated pressure strain loop, suggesting a stiff left ventricle with low global strain and low work efficiency.
Legend to Fig 7
Fig 7. 2 D strain imaging of the right ventricle. Applying a ”3-click” method that is by placing the cursor at the two basal and the third at the apical segment, the software simultaneously generates TAPSE, FAC% and global strain in no time, thereby facilitating an accurate assessment of RV systolic function.