Figure 3. A) Correlation between differences in the first derivative of pupil size changes and Von Frey tactile sensitivity thresholds between body locations over time. B) Functional uncorrected significance tests for these correlations. Thep -values are log-transformed, the ticks on the y-axis indicate the respective steps. Both correlations between the finger and calf, and the arm and calf reached statistical significance after about 0.5 to 0.6 s and lasted up to 0.7 s.