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Non-coding RNAs to treat vascular smooth cell dysfunction
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  • Simon Brown,
  • Eftychia Klimi,
  • Wilfried Bakker,
  • Abdelaziz Beqqali,
  • Andrew Baker
Simon Brown
The University of Edinburgh Centre for Cardiovascular Science
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Eftychia Klimi
The University of Edinburgh Centre for Cardiovascular Science
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Wilfried Bakker
Batavia Biosciences BV
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Abdelaziz Beqqali
The University of Edinburgh Centre for Cardiovascular Science
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Andrew Baker
The University of Edinburgh Centre for Cardiovascular Science

Corresponding Author:[email protected]

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Abstract

Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular diseases, including atherosclerosis, restenosis, and vein graft failure. Recent advances have unveiled a fascinating breadth of non-coding RNAs (ncRNAs) that play a pivotal role in regulating vSMC function. This review aims to provide an in-depth analysis of the mechanisms underlying vSMC dysfunction and the therapeutic potential of various ncRNAs in mitigating this dysfunction, either preventing or reversing it. We explore the intricate interplay of microRNAs, long-non-coding RNAs and circular RNAs, shedding light on their roles in regulating key signalling pathways associated with vSMC dysfunction. Moreover, we discuss the prospects and challenges associated with developing ncRNA based therapies for this prevalent cardiovascular pathology.
17 Nov 2023Submitted to British Journal of Pharmacology
17 Nov 2023Submission Checks Completed
17 Nov 2023Assigned to Editor
17 Nov 2023Reviewer(s) Assigned
19 Feb 20241st Revision Received
11 Mar 2024Review(s) Completed, Editorial Evaluation Pending
14 Mar 2024Editorial Decision: Accept