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Design and Synthesis of [2.2]Paracyclophane-based Oxazole-Pyrimidine Ligands and Application in Nickel-Catalyzed 1,2-Reduction of α,β-Unsaturated Ketones
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  • Juan Wang,
  • Qing-Xian Xie,
  • Xiang Li ,
  • Chang-Bin Yu,
  • Yong-Gui Zhou
Juan Wang
Dalian University of Technology
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Qing-Xian Xie
Chinese Academy of Sciences Dalian Institute of Chemical Physics
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Xiang Li
Dalian University of Technology
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Chang-Bin Yu
Chinese Academy of Sciences Dalian Institute of Chemical Physics
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Yong-Gui Zhou
Chinese Academy of Sciences Dalian Institute of Chemical Physics

Corresponding Author:[email protected]

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Abstract

The [2.2]paracyclophane-derived oxazole-pyrimidine ligands with planar chirality (PYMCOX) were designed, synthesized and successfully applied in nickel-catalyzed asymmetric 1,2-reduction of α,β-unsaturated ketones, affording the chiral allylic alcohols with up to 99% yield and 99% ee. Meanwhile, this reduction reaction could be conducted on gram-scale without loss of activity and enantioselectivity, and the chiral ligand could be conveniently recovered with high yield.
21 Nov 20231st Revision Received
22 Nov 2023Submission Checks Completed
22 Nov 2023Assigned to Editor
22 Nov 2023Review(s) Completed, Editorial Evaluation Pending
22 Nov 2023Editorial Decision: Accept