entry
|
reagent
(equiv)
|
DIB
(equiv)
|
H2O
(mL)
|
Solvent
(2.5 mL)
|
Time
(h)
|
Yieldb
(%)
|
1 |
NaCl (1) |
1 |
0.5 |
DCM |
3 |
4a (32) |
2 |
NaCl (1) |
2 |
0.5 |
DCM |
3 |
4a (35) |
3 |
NaCl (1) |
3 |
0.5 |
DCM |
3 |
4a (36) |
4 |
NaCl (1) |
3.5 |
0.5 |
DCM |
3 |
4a (38) |
5 |
NaCl (1) |
4 |
0.5 |
DCM |
3 |
4a (39) |
6 |
NaCl (1.5) |
3.5 |
0.5 |
DCM |
3 |
4a (41) |
7 |
NaCl (1.5) |
3.5 |
- |
DCM |
3 |
4a (0) |
8 |
NaCl (3) |
3.5 |
0.1 |
DCM |
3 |
4a (51) |
9 |
NaCl (3) |
3.5 |
0.3 |
DCM |
3 |
4a (57) |
10 |
NaCl (3) |
3.5 |
0.5 |
DCM |
3 |
4a (62) |
11 |
NaCl (3) |
3.5 |
0.7 |
DCM |
3 |
4a (61) |
12 |
NaCl (3) |
3.5 |
1 |
DCM |
3 |
4a (56) |
13 |
NaCl (3) |
3.5 |
0.5 |
DMSO |
3 |
4a (0) |
14 |
NaCl (3) |
3.5 |
0.5 |
DMF |
3 |
4a (0) |
15 |
NaCl (3) |
3.5 |
0.5 |
EtOH |
3 |
4a (14) |
16 |
NaCl (3) |
3.5 |
0.5 |
DCM |
1 |
4a (54) |
17 |
NaCl (3) |
3.5 |
0.5 |
DCM |
2 |
4a (59) |
18 |
NaCl (3) |
3.5 |
0.5 |
DCM |
3 |
4a (62) |
19 |
NaCl (3) |
3.5 |
0.5 |
DCM |
4 |
4a (70) |
20 |
NaCl (3) |
3.5 |
0.5 |
DCM |
5 |
4a (80) |
21 |
NaCl (3) |
3.5 |
0.5 |
DCM |
6 |
4a (79) |
22 |
KCl (1.5) |
3.5 |
0.5 |
DCM |
5 |
4a (26) |
23 |
CuCl2(1.5) |
3.5 |
0.5 |
DCM |
5 |
4a
(0) |
24c
|
NaCl (1.5) |
3.5 |
0.5 |
DCM |
5 |
4a (32) |
25d
|
NaCl (1.5) |
3.5 |
0.5 |
DCM |
5 |
4a (0) |
26 |
KBr(1.3) |
3.5 |
0.5 |
DCM |
5 |
4b (64) |
27e
|
- |
1 |
0.5 |
DCM |
14 |
4c
(69) |