Critical Appraisal
The most common deficiencies in reporting related to granularity of
demographics and disease characteristics (Supplemental Table S2). Only 1
study specifically focused on reporting infectious complications, and
this study provided granular details for characteristics of each
infection (n= 12 patients and 15 infections). The remaining 29 studies
aimed to report clinical outcomes of sirolimus treatment, and they
provided less detail about infections. For example, fewer than 20% of
studies reported the following characteristics specific to the
participants with infections: age, sex, sites of VA disease, and whether
sirolimus was held.