Search Strategy
A medical librarian (LHY) searched the literature for records including the concepts of VAs, sirolimus, rapamycin, everolimus, and infection. This search strategy included broad categories (e.g. vascular anomaly, vascular malformation, vascular tumor), types of VAs (e.g. hemangioma, lymphatic malformation, hemangioendothelioma), and syndromes (e.g. CLOVES, Sturge-Weber Syndrome, Klippel-Trenaunay Syndrome). We included disorders listed in the International Society for the Study of Vascular Anomalies classification of vascular anomalies. The librarian created search strategies using a combination of keywords and controlled vocabulary in Embase.com 1947- , Ovid Medline 1946- , Scopus 1823- , and Cochrane Central Register of Controlled Trials (CENTRAL). All search strategies were completed November 11, 2022 with no added limits. Book chapters, conference papers, editorials, and systematic reviews were removed when possible. A total of 3,874 results were found. 302 duplicate records were deleted after using the de-duplication processes described in “De-duplication of database search results for systematic reviews in EndNote,”22 resulting in a total of 3,572 unique citations included in the project library. Fully reproducible search strategies for each database can be found in Appendix 1.