Patient Characteristics (n=290) n (%)
Types of Vascular Anomalies Types of Vascular Anomalies Types of Vascular Anomalies
Vascular Tumors
KHE/Tufted Angioma a 24 (8)
Epithelioid Hemangioendothelioma 8 (3)
Vascular Malformations
Complex Lymphatic Anomaly b 7 (2)
PIK3CA-Related Overgrowth Spectrum 18 (6)
Slow Flow Vascular Malformation 60 (21)
Arteriovenous Malformation 3 (1)
Blue Rubber Bleb Nevus Syndrome 1 (<1)
Multiple Vascular Anomalies 169 (58)
Type of Infection c (n=315 total infections) Type of Infection c (n=315 total infections) Type of Infection c (n=315 total infections)
Upper Respiratory Infection / ”Viral Infection” d 137 (54)
Pneumonia e 52 (20)
Cutaneous Infection 20 (8)
Gastroenteritis 14 (5)
Urinary Tract Infection/Pyelonephritis 7 (3)
Lymph Gland Infection 11 (4)
Bacteremia 4 (1)
Osteomyelitis/Septic Arthritis 3 (1)
Meningitis 2 (<1)
Herpes Reactivation 2 (<1)
Infectious thrombophlebitis 1 (<1)
Culture Negative Sepsis 1 (<1)
CMV 1 (<1)
CTCAE Grade of Infections f CTCAE Grade of Infections f
1 to 2 194 (66)
3 to 4 95 (32)
5 6 (2)
Sirolimus Trough (Target or Actual) g Sirolimus Trough (Target or Actual) g
2 to 5 21 (9)
5 to 10 49 (20)
5 to 15 5 (2)
10 to 15 159 (65)
>15 11 (4)
Antibiotic Prophylaxis h Antibiotic Prophylaxis h
Penicillin 1 (<1)
PJP Prophylaxis 175 (80)
None 42 (19)