Abbreviations:
KHE, kaposiform hemangioendothelioma; CMV, cytomegalovirus; PJP,pneumocystis jirovecii pneumonia. a In KHE
category, 11 patients with Kasabach Merrit Phenomenon (KMP), 12 patients
in which KMP was not specified, and 1 patient with Tufted Angioma.b In Complex Lymphatic Anomaly category, 4 patients
with Generalized Lymphangiomatosis, 2 patients with Gorham Stout
Disease, and 1 patient with Central Conducting Lymphatic Anomaly.cMore than one infection was noted for some patients,
so number of infections exceeds number of reported patients.
Additionally, the type of infection was not specified for 60
patients.d URI/”Viral Infections” includes reported
cases of Flu and COVID-19. e Pneumonia category
includes 5 bacterial pathogens (including 1 pneumocystis
jirovecii pneumonia), 8 viral pathogens, and 39 unspecified pathogens.f Grade of infection was not reported for 20
infections. g While some reported actual trough prior
to infection, the vast majority of studies reported the goal range of
troughs maintained during treatment. Of note, 16 participants counted in
the “2 to 5” range were actually reported at “2 to 6”. Similarly, in
the “5 to 10” range, 25 were actually reported as “4 to 12” and 8
were reported as “4 to 13”. Sirolimus dosing was not specified for 45
patients. h Antibiotic prophylaxis was not specified
for 72 patients.
Table 3. Characteristics of Fatal
Infections (n=5)