Critical Appraisal
The most common deficiencies in reporting related to granularity of demographics and disease characteristics (Supplemental Table S2). Only 1 study specifically focused on reporting infectious complications, and this study provided granular details for characteristics of each infection (n= 12 patients and 15 infections). The remaining 29 studies aimed to report clinical outcomes of sirolimus treatment, and they provided less detail about infections. For example, fewer than 20% of studies reported the following characteristics specific to the participants with infections: age, sex, sites of VA disease, and whether sirolimus was held.