Search Strategy
A medical librarian (LHY) searched the literature for records including
the concepts of VAs, sirolimus, rapamycin, everolimus, and infection.
This search strategy included broad categories (e.g. vascular anomaly,
vascular malformation, vascular tumor), types of VAs (e.g. hemangioma,
lymphatic malformation, hemangioendothelioma), and syndromes (e.g.
CLOVES, Sturge-Weber Syndrome, Klippel-Trenaunay Syndrome). We included
disorders listed in the International Society for the Study of Vascular
Anomalies classification of vascular anomalies. The librarian created
search strategies using a combination of keywords and controlled
vocabulary in Embase.com 1947- , Ovid Medline 1946- , Scopus 1823- , and
Cochrane Central Register of Controlled Trials (CENTRAL). All search
strategies were completed November 11, 2022 with no added limits. Book
chapters, conference papers, editorials, and systematic reviews were
removed when possible. A total of 3,874 results were found. 302
duplicate records were deleted after using the de-duplication processes
described in “De-duplication of database search results for systematic
reviews in EndNote,”22 resulting in a total of 3,572
unique citations included in the project library. Fully reproducible
search strategies for each database can be found in Appendix 1.