Results
Patient demographics and lesion site: Hundred and ten patients were enrolled in this study. The male: female ratio was 1:4 and the average age of the patients was 63 years old (ranged 33 yo- 93 yo). Majority of the lesions 54/113 (47.8 %) were located in the T-zone region (ear, eye, nose, lip, and chin), followed by 39/113 (34.5%) in the head and neck region (scalp, forehead, cheek, and neck), 14/113 (12.4%) on the extremities (arms, legs, hands, and feet), and only 6/113 (5.3%) on trunk and genitalia.
Histopathology diagnosis of the tissue samples collected(Supplemental Table 1) . A total of 113 tissues were collected and imaged with the FF-OCT device. Of which, 95 (84 %) were positive for tumor including 73 (65%) BCCs, 15 (13%) SCCs, 2 basosquamous cell carcinoma (2%), and 5 others (4%). The most common BCC sub-type was the nBCC 46 (41%), followed by 43 (38%) infiltrative BCC (iBCC) or micro-nodular BCC (mnBCC) and the least common subtype was superficial BCCs (sBCC) 3 (3%). The rest 18/113 tissues (15.9%) were negative for tumors.