ABSTRACT
Objectives: Existing knowledge on Health Related Quality of
Life (HRQoL) after surgical removal of sinonasal inverted papilloma (IP)
is limited. Moreover, predictors for a better or worse postoperative
HRQoL outcome are not known. Our aim was to assess HRQoL in all three
health domains (physical, psychological and social), track its
postoperative trajectory, investigate if preoperative observations could
predict distinct postoperative HRQoL outcomes, and evaluate whether
physicians’ interventions could contribute to improved postoperative
HRQoL.
Design: Prospective cohort study.
Setting: Tertiary referral hospital.
Participants: Seventy-four patients who underwent surgery for
an IP were included. They were asked to fill in the Endonasal Endoscopic
Sinus and Skull Base Surgery Questionnaire (EES-Q) preoperatively, and
then two weeks, three months, and one year postoperatively.
Main outcome measures: Linear mixed models (LMM) analyses were
performed to evaluate the overall postoperative HRQoL and the separate
health domains, as well as the impact of specific variables (sex, age,
ASA classification, smoker, Krouse staging, preoperative EES-Q score,
type of surgery and postoperative antibiotics) on HRQoL improvement.
Results: The total EES-Q score (P<.001) as well as
the physical (P<.001), psychological (P=.049), and the social
(P=.002) domains significantly improved postoperatively. ASA
classification (P=.049), preoperative EES-Q score (P<.001) and
postoperative antibiotics (P=.036) were significant variables.
Conclusions: Overall HRQoL, as well as each of the three health
domains, improved significantly. A higher ASA score, a higher
preoperative EES-Q score, and the administration of postoperative
antibiotics were significant predictors for better HRQoL recovery
postoperatively. Further research is necessary to confirm these results.