Open questions which can be addressed with human hypoxia models
Human hypoxia models can help address several open questions in COPD
research. The direct impact of hypoxia on the development of
atherosclerosis in COPD, independent of associated inflammation, can be
investigated. The effects of different levels and durations of hypoxic
exposure on COPD progression, exacerbations, and the underlying
mechanisms can also be explored [72]. Furthermore, the optimization
of treatments for respiratory failure in COPD during both type I and
type II phases can be studied using human hypoxia models.