Open questions which can be addressed with human hypoxia models
Human hypoxia models offer a unique opportunity to address several open
questions in migraine research. For instance, the impact of hypoxia on
the trigeminovascular system and its contribution to migraine attacks
can be studied in controlled settings. Understanding how hypoxia affects
the release of vasoactive substances, neuronal excitability, and the
propagation of CSD can provide insights into the triggers and mechanisms
of migraine. Additionally, human hypoxia models can shed light on the
interplay between hypoxia and other migraine triggers, such as stress,
exercise, or sleep disturbances [92]. Investigating how hypoxia
interacts with these triggers and influences migraine susceptibility can
help uncover the complex interactions between multiple factors involved
in migraine pathogenesis. Furthermore, studying the effects of hypoxia
on sensory processing and perception may provide insights into the
mechanisms underlying migraine-associated sensory hypersensitivity
[93].