Limitations of the OSA hypoxia model
There are notable construct barriers such as how the model primarily focuses on the hypoxic aspect of OSA and may not fully capture the complexities of other contributing factors, such as airway collapse and sleep fragmentation. Additionally, the duration and frequency of hypoxic exposure in experimental settings may not perfectly replicate the intermittent hypoxia experienced during sleep apnea episodes. Individual variations and comorbidities in OSA patients, as well as the influence of sleep architecture, may affect the response to hypoxia and limit generalizability. Therefore, careful interpretation and consideration of these limitations are necessary when using the OSA hypoxia model.