Open questions which can be addressed with human hypoxia models
Human hypoxia models offer a unique opportunity to address several open questions in migraine research. For instance, the impact of hypoxia on the trigeminovascular system and its contribution to migraine attacks can be studied in controlled settings. Understanding how hypoxia affects the release of vasoactive substances, neuronal excitability, and the propagation of CSD can provide insights into the triggers and mechanisms of migraine. Additionally, human hypoxia models can shed light on the interplay between hypoxia and other migraine triggers, such as stress, exercise, or sleep disturbances [92]. Investigating how hypoxia interacts with these triggers and influences migraine susceptibility can help uncover the complex interactions between multiple factors involved in migraine pathogenesis. Furthermore, studying the effects of hypoxia on sensory processing and perception may provide insights into the mechanisms underlying migraine-associated sensory hypersensitivity [93].