Limitations of the OSA hypoxia model
There are notable construct barriers such as how the model primarily
focuses on the hypoxic aspect of OSA and may not fully capture the
complexities of other contributing factors, such as airway collapse and
sleep fragmentation. Additionally, the duration and frequency of hypoxic
exposure in experimental settings may not perfectly replicate the
intermittent hypoxia experienced during sleep apnea episodes. Individual
variations and comorbidities in OSA patients, as well as the influence
of sleep architecture, may affect the response to hypoxia and limit
generalizability. Therefore, careful interpretation and consideration of
these limitations are necessary when using the OSA hypoxia model.