Disease mechanisms which can be modelled with experimental
hypoxia
Experimental hypoxia models have been used to study the mechanisms
underlying kidney dysfunction. Hypoxia, or reduced oxygen availability,
can occur in various renal diseases due to impaired blood flow,
ischemia, or inadequate oxygenation [99]. Hypoxia can trigger
cellular responses, including the activation of hypoxia-inducible
factors (HIFs), which play a crucial role in adaptive mechanisms to
maintain cellular homeostasis under low-oxygen conditions [100].
Experimental hypoxia models can simulate and study the impact of reduced
oxygen levels on kidney cells and tissues, providing insights into the
molecular and cellular responses involved in renal hypoxia-related
diseases.
Furthermore, experimental hypoxia models allow researchers to
investigate the effects of hypoxia on renal blood flow, glomerular
filtration rate, tubular function, and electrolyte handling. These
models can simulate renal ischemia-reperfusion injury, a common cause of
acute kidney injury, and elucidate the mechanisms underlying renal
tissue damage, inflammation, and impaired renal function in hypoxic
conditions.