Open questions which can be addressed with human hypoxia models
Human hypoxia models offer valuable opportunities to address several
open questions regarding kidney function and hypoxia-related diseases.
These models can help elucidate the cellular and molecular responses of
the kidneys to hypoxic stress in real-time, providing insights into the
adaptive mechanisms and potential therapeutic targets. Furthermore,
human hypoxia models can aid in studying the interplay between hypoxia
and other factors contributing to kidney disease progression, such as
oxidative stress, inflammation, and metabolic disturbances.
By utilizing human hypoxia models, researchers can investigate the
effects of controlled oxygen levels on specific renal cell types,
including proximal tubular cells, podocytes, and endothelial cells
[101]. This can enhance our understanding of the impact of hypoxia
on cellular metabolism, cell death pathways, and cellular communication
within the renal microenvironment. Additionally, human hypoxia models
can help explore the potential benefits of oxygen-based therapies and
interventions in kidney diseases [102].