Open questions which can be addressed with human hypoxia models
Human hypoxia models can help address several open questions in COPD research. The direct impact of hypoxia on the development of atherosclerosis in COPD, independent of associated inflammation, can be investigated. The effects of different levels and durations of hypoxic exposure on COPD progression, exacerbations, and the underlying mechanisms can also be explored [72]. Furthermore, the optimization of treatments for respiratory failure in COPD during both type I and type II phases can be studied using human hypoxia models.