Open questions which can be addressed with human hypoxia models
Human hypoxia models offer valuable opportunities to address several open questions regarding kidney function and hypoxia-related diseases. These models can help elucidate the cellular and molecular responses of the kidneys to hypoxic stress in real-time, providing insights into the adaptive mechanisms and potential therapeutic targets. Furthermore, human hypoxia models can aid in studying the interplay between hypoxia and other factors contributing to kidney disease progression, such as oxidative stress, inflammation, and metabolic disturbances.
By utilizing human hypoxia models, researchers can investigate the effects of controlled oxygen levels on specific renal cell types, including proximal tubular cells, podocytes, and endothelial cells [101]. This can enhance our understanding of the impact of hypoxia on cellular metabolism, cell death pathways, and cellular communication within the renal microenvironment. Additionally, human hypoxia models can help explore the potential benefits of oxygen-based therapies and interventions in kidney diseases [102].