Limitations of the COPD hypoxia model
It should be noted that the model may not fully replicate the complex
pathophysiology of COPD: as the disease involves multiple factors beyond
hypoxia, such as chronic inflammation, respiratory endothelial failure
and airway remodeling. Additionally, individual variations and
comorbidities associated with COPD, including cardiovascular diseases,
may influence the response to hypoxia and limit generalizability.
Cautious interpretation and consideration of these limitations are
necessary when using the COPD hypoxia model.