µSI Process Analyzer System
The biomanufacturing industry has long aspired to achieve real-time
monitoring and control of biological manufacturing processes to
efficiently produce final products with desired product quality
attribute (PQA) profiles. With the aim of developing a system capable of
automatic end-to-end sample preparation, and to interface online/at-line
sample sources with analytical instruments to achieve multi-fold
acceleration in acquiring process performance and product quality
insights, the µSI process analyzer system was designed and engineered.
The µSI process analyzer system comprises two compartments: the upper
sample processing compartment and the lower power supply compartment.
The sample processing compartment consists of four quadrants equipped
with syringe pumps with glass syringes, solvent selection valves, heated
coils, a degasser, solenoid valves, and a reagent cooler, all integrated
to minimize the fluidic path. This compact design reduces the footprint
and enables on-the-floor technology implementation.