µSI Process Analyzer System
The biomanufacturing industry has long aspired to achieve real-time monitoring and control of biological manufacturing processes to efficiently produce final products with desired product quality attribute (PQA) profiles. With the aim of developing a system capable of automatic end-to-end sample preparation, and to interface online/at-line sample sources with analytical instruments to achieve multi-fold acceleration in acquiring process performance and product quality insights, the µSI process analyzer system was designed and engineered. The µSI process analyzer system comprises two compartments: the upper sample processing compartment and the lower power supply compartment. The sample processing compartment consists of four quadrants equipped with syringe pumps with glass syringes, solvent selection valves, heated coils, a degasser, solenoid valves, and a reagent cooler, all integrated to minimize the fluidic path. This compact design reduces the footprint and enables on-the-floor technology implementation.