3.7 Functional classification of domain interaction types using
Gene Ontology
Next, we explored if there are functional preferences between permanent
and transient domains. As our dataset consists of proteins from various
genomes, we only considered the genome which populates the maximum
number of proteins in our dataset. Using Gene Ontology functional
classification analysis, we observed that both permanent and transient
domain containing proteins in humans are involved in similar kinds of
biological processes, molecular functions and belong to similar protein
classes, and there is no bias (Supplementary Figure S3). The variance in
functional roles may be seen if the whole dataset is compared, and this
needs more sophisticated algorithms, which are out of scope at present.