3.7 Functional classification of domain interaction types using Gene Ontology
Next, we explored if there are functional preferences between permanent and transient domains. As our dataset consists of proteins from various genomes, we only considered the genome which populates the maximum number of proteins in our dataset. Using Gene Ontology functional classification analysis, we observed that both permanent and transient domain containing proteins in humans are involved in similar kinds of biological processes, molecular functions and belong to similar protein classes, and there is no bias (Supplementary Figure S3). The variance in functional roles may be seen if the whole dataset is compared, and this needs more sophisticated algorithms, which are out of scope at present.