loading page

Strategies for the statins production in microbial cell factory:present and future
  • +2
  • Dexun Fan,
  • HuaYang Tang,
  • Fengguang Zhao,
  • Xiaorong Yang,
  • Shuangyan Han
Dexun Fan
South China University of Technology
Author Profile
HuaYang Tang
South China University of Technology
Author Profile
Fengguang Zhao
South China University of Technology
Author Profile
Xiaorong Yang
South China University of Technology
Author Profile
Shuangyan Han
South China University of Technology

Corresponding Author:[email protected]

Author Profile

Abstract

Statins as a lipid-lowering drug can selectively inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and decrease cholesterol synthesis effectively. With the improvement of nutritional conditions, the demand for statins is increasing in global market. Due to the rapid development of modern biotechnologies, the biosynthesis of stains by microbial cell factory appears great advantages. It has the advantages of simple operation and easy separation of products. This review summarized the strategies on statins production via microbial cell factory, including both traditional fermentation culture and modern synthetic biology manufacture. Firstly, the complex fermentation parameters and process control technology on submerged fermentation (SmF) and solid-state fermentation (SSF) were introduced in detail. Especially, the possibility of recoverable agricultural wastes/(Biomass) as fermentation substrate on solid-state fermentation to produce statins was emphasized. Besides, metabolic engineering strategies to construct robust engineering strains and strains evolution were also discussed. The review highlights the potential and challenge of microbial cell factory to yield the statins. Thus, it will facilitate the production of statins in more green production mode.
19 May 2023Submitted to Biotechnology Journal
22 May 2023Submission Checks Completed
22 May 2023Assigned to Editor
23 May 2023Reviewer(s) Assigned
12 Jun 2023Review(s) Completed, Editorial Evaluation Pending
13 Jun 2023Editorial Decision: Revise Major
25 Jul 20231st Revision Received
25 Jul 2023Submission Checks Completed
25 Jul 2023Assigned to Editor
25 Jul 2023Reviewer(s) Assigned
31 Jul 2023Review(s) Completed, Editorial Evaluation Pending
01 Aug 2023Editorial Decision: Revise Minor
02 Aug 20232nd Revision Received
02 Aug 2023Submission Checks Completed
02 Aug 2023Assigned to Editor
02 Aug 2023Review(s) Completed, Editorial Evaluation Pending
04 Aug 2023Editorial Decision: Accept