Conclusions
We found a very small risk of priapism with PDE5i compared with other
ADRs. The use of PDE5i among young patients is associated with a higher
risk of priapism compared to adults, albeit low. Our analysis further
confirms that the risk of priapism amongst older men with ED is
extremely rare. This implies that although patient counseling when
prescribing PDE5is for adults seems unneeded, providers should be made
aware of the higher risk of priapism in under-age patients, and
regulations may be useful to reduce their access to products containing
PDE5is.