Conclusions
We found a very small risk of priapism with PDE5i compared with other ADRs. The use of PDE5i among young patients is associated with a higher risk of priapism compared to adults, albeit low. Our analysis further confirms that the risk of priapism amongst older men with ED is extremely rare. This implies that although patient counseling when prescribing PDE5is for adults seems unneeded, providers should be made aware of the higher risk of priapism in under-age patients, and regulations may be useful to reduce their access to products containing PDE5is.