Diphtheria, tetanus and pertussis vaccines
Confirmed allergic reactions to diphtheria, tetanus and pertussis vaccines are very rare comprising both urticaria or hives36 both anaphylaxis37. Injection site reactions to DTaP have rarely been reported, some referred to delayed hypersensitivity to aluminum included in the vaccine as adjuvant38. DTaP and Tdap vaccines might include traces of cow’s milk proteins, in particular casamino acids. Some cases of anaphylactic reactions to booster doses of DTaP or Tdap in children and adolescents with a documented history of severe milk allergy have been reported39 although most patients with severe milk allergy have tolerated such vaccines. Thus, vaccination of children allergic to cow’s milk is considered safe1,17.