Pneumococcal vaccines
Pneumococcal vaccines contain inactivated diphtheria toxin (CRM 197), used as carrier protein, and Polysorbate 80 (PS80) which are adsorbed on aluminum phosphate. CRM 197 was implicated as cause of anaphylaxis in one case after administration of pneumococcal conjugate vaccine42. Aluminum phosphate may be cause of injection site nodules38, a delayed type hypersensitivity, but it is not a contraindication to subsequent vaccination. Previous severe hypersensitivity reactions to the same vaccine or its components, mostly CRM 197 are the only contraindications to pneumococcal vaccines.