Gelatine allergy
Gelatine is an animal protein derived from bovine and porcine connective tissue. It is used in amounts that range from micrograms to milligrams as a stabiliser in viral attenuated vaccines in order to protect them against unfavourable conditions52. Despite extremely rare, in case of allergy to animal gelatine or to galactose-alpha-1,3-galactose (α-Gal) contained in mammalian meat, a gelatine-free vaccine is the first choice. Anyway to assess sensitization to gelatine the allergy workup is based on: I) skin prick testing performed with 5g gelatine powder diluted in 5 ml saline52 and mammalian meet extract; II) serological test with the determination of specific IgE to mammalian meet and galactose-alpha-1,3-galactose (α-Gal).