Diphtheria, tetanus and pertussis vaccines
Confirmed allergic reactions to diphtheria, tetanus and pertussis
vaccines are very rare comprising both urticaria or
hives36 both anaphylaxis37.
Injection site reactions to DTaP have rarely been reported, some
referred to delayed hypersensitivity to aluminum included in the vaccine
as adjuvant38. DTaP and Tdap vaccines might include
traces of cow’s milk proteins, in particular casamino acids. Some cases
of anaphylactic reactions to booster doses of DTaP or Tdap in children
and adolescents with a documented history of severe milk allergy have
been reported39 although most patients with severe
milk allergy have tolerated such vaccines. Thus, vaccination of children
allergic to cow’s milk is considered safe1,17.