KEY MESSAGE
The purpose of this review is to provide clinicians with a concise and practical review which summarize how to manage in the clinical settings allergic children which have to undergo immunization practices. For this reason, the manuscript is divided into two parts: the first one concerns the clinical aspects of allergic reactions to vaccines, while the second is about the management both of the children with a suspected allergic reaction to a previous vaccine and the need to continue the vaccination schedule, both of the children with a history of allergy to a vaccine component.