Pneumococcal vaccines
Pneumococcal vaccines contain inactivated diphtheria toxin (CRM 197),
used as carrier protein, and Polysorbate 80 (PS80) which are adsorbed on
aluminum phosphate. CRM 197 was implicated as cause of anaphylaxis in
one case after administration of pneumococcal conjugate
vaccine42. Aluminum phosphate may be cause of
injection site nodules38, a delayed type
hypersensitivity, but it is not a contraindication to subsequent
vaccination. Previous severe hypersensitivity reactions to the same
vaccine or its components, mostly CRM 197 are the only contraindications
to pneumococcal vaccines.