RPT |
NET cell lines derived spheroids |
177Lu-DOTATATE |
Evaluation of radiosensitizer drugs. |
93, 97, 98 |
|
mouse derived tumor spheroids |
68Ga-DOTATATE |
Demonstrate the utility of radiotracers in measure therapeutic effect of
RPT. |
84 |
Tumor neoantigens |
Patient-derived CRC organoids |
– |
Demonstrate
that the organoids are feasible for investigating neoantigen
presentation in vitro. |
106 |
|
Patient-derived hepatobiliary tumor organoids |
– |
Identify the
predicted antigenic peptides that can activate T lymphocytes using
organoids. |
107 |
|
Patient-derived single cell CRC organoids |
– |
Demonstrate that
the HLA class Ⅰ peptide presentation landscape was heterogeneous even
within one individual. |
110 |
Cell-penetrating peptides |
Human primary cell derived multicellular BBB
organoids |
SynB1, L-2, PreS2-TLM Transportan 10, SAP, SAP(E), SVM3,
SVM4, Bip(1), Bip(2), (PPR)3, (PPR)5, DPV1047, DPV15, HIV-1 Tat,
Penetratin, Engrailed-2, HoxA-13, Polyarginine |
Demonstrate the
feasibility of BBB organoid models for cost-effective and
high-throughput CPP screening. |
114,
120 |
|
Human primary cell derived multicellular BBB organoids |
Perfluoroarene-based, macrocyclic analogues of transportan-10 |
Demonstrate that abiotic peptide macrocycles exhibit increased capacity
for penetrating to the brain using BBB organoids. |
121 |
Host defense peptides |
Patients and healthy lung ALI organoids |
– |
Demonstrate the utility of ALI organoids to study the function of HDPs
in respiratory diseases. |
128-130 |
|
Human primary cell derived lung ALI organoids |
Esc (1-21) |
Demonstrate strong potential of Esc (1-21) in protecting the P.
aeruginosa infection using ALI organoids. |
131 |
|
Human alveolar lung cell line derived ALI organoids |
AA139, M33 |
Demonstrate that ALI organoids are promising models to predict acute
lung toxicity through assessment of various combinations of HDPs and
nanocarriers. |
132 |
Other therapeutic peptides |
Patient-derived CRC organoids |
staple
peptides SAHPA1 and xStAx |
Demonstrate the potential of these peptides
as a novel anti-cancer drug using organoids. |
134 |
|
Adult mice intestinal epithelium derived organoids |
dFz7-21 (a peptide specifically
binding to FZD7) |
Demonstrate that dFz7-21 inhibit stem cell function
in intestinal organoids. |
137 |