3.4 Grandmaternal iAs exposure alters life-long body composition
in male and female F2 offspring
iAs-induced low wean weights recovered in F2 pups, but life-long body
weight reductions persisted. Wean weights in F2 females were
unremarkable, whereas F2 10 ppb male mice had significantly higher wean
weight compared to the control (Figure 5.A ). F2 females had no
significant differences in body weight through 40 weeks of age
(Figure 5.B) . Remarkably, F2 male mice in all treatment groups
had significantly lower body weight compared to control starting at week
28 that persisted through 40 weeks of age (Figure 5.C ). Similar
results were seen in body mass to fat pad mass ratios (Figure
6 ). Consistent with low body weight, F2 males in the 10 ppb and 2300
ppb iAs exposure groups had significantly lower body mass to fat pad
mass ratio (Figure 6.B) . No significant differences were seen
in F2 female final body composition (Figure 6.A).