3.4 Grandmaternal iAs exposure alters life-long body composition in male and female F2 offspring
iAs-induced low wean weights recovered in F2 pups, but life-long body weight reductions persisted. Wean weights in F2 females were unremarkable, whereas F2 10 ppb male mice had significantly higher wean weight compared to the control (Figure 5.A ). F2 females had no significant differences in body weight through 40 weeks of age (Figure 5.B) . Remarkably, F2 male mice in all treatment groups had significantly lower body weight compared to control starting at week 28 that persisted through 40 weeks of age (Figure 5.C ). Similar results were seen in body mass to fat pad mass ratios (Figure 6 ). Consistent with low body weight, F2 males in the 10 ppb and 2300 ppb iAs exposure groups had significantly lower body mass to fat pad mass ratio (Figure 6.B) . No significant differences were seen in F2 female final body composition (Figure 6.A).