3.5 Dysregulated glucose metabolism in adult F2 male and F2 female
mice
We measured blood glucose at three lifetime points (8, 25, and 38 weeks)
within the F2 exposure groups to understand the effects of grandmaternal
exposure on adult F2 diabetic phenotypes. The F0 exposure of 245 ppb
causes a T2D phenotype in F2 female mice starting at an early age (3
weeks) that is persistent through adulthood (38 weeks) (Figure
7.A ). In addition, F2 male mice developed dysregulated glucose
metabolism only in late life (38 weeks) (Figure 7.B ). We
identified no significant changes in AUC analysis (Supplemental
Figure 4.A and 4.B ). These results indicate primordial germ cells are
damaged by grandmaternal iAs exposure and result in adult metabolic
disruption that is dose-specific.