AUTHORS’ CONTRIBUTIONS
B.P., B.B. and R.A.J conceived the initial study concept. B.B. and
R.A.J. developed the manual CaSc concept. J.L. programmed the AutoCaSc
tools and performed the computational analyses under the supervision of
B.P. and R.A.J.. B.B. and R.A.J. created the pre-print draft
(https://doi.org/10.1101/588517), concept and figures. B.P. performed
bioinformatic analyses to align, call and annotate the exome files used
in the validation experiments. J.L. and B.P. created Figures 1, 2 and
Table 1, 2 and the Supplementary materials. C.K. and K.P. performed the
manual CaSc annotations and aided in the development of the score. B.P,
J.L. and R.A.J wrote and edited the manuscript. All authors reviewed and
commented on the final draft manuscript.