AUTHORS’ CONTRIBUTIONS

B.P., B.B. and R.A.J conceived the initial study concept. B.B. and R.A.J. developed the manual CaSc concept. J.L. programmed the AutoCaSc tools and performed the computational analyses under the supervision of B.P. and R.A.J.. B.B. and R.A.J. created the pre-print draft (https://doi.org/10.1101/588517), concept and figures. B.P. performed bioinformatic analyses to align, call and annotate the exome files used in the validation experiments. J.L. and B.P. created Figures 1, 2 and Table 1, 2 and the Supplementary materials. C.K. and K.P. performed the manual CaSc annotations and aided in the development of the score. B.P, J.L. and R.A.J wrote and edited the manuscript. All authors reviewed and commented on the final draft manuscript.