Data Availability
Ambry Genetic supports open data sharing. All data supporting the work
presented here can be found at
www.genematcher.org or in the
supplemental files attached. Further, classified alterations identified
during diagnostic testing are deposited into ClinVar.
Ethics approval
All HIPAA-covered patient identifiers were removed. Western
Institutional Review Board determined the study to be exempt from the
Office for Human Research Protections Regulations for the Protection of
Human Subjects (45 CFR 46) under category 4. Retrospective data analysis
of anonymized data exempted the study from the requirement to receive
consent from patients.