Data Availability
Ambry Genetic supports open data sharing. All data supporting the work presented here can be found at www.genematcher.org or in the supplemental files attached. Further, classified alterations identified during diagnostic testing are deposited into ClinVar.
Ethics approval
All HIPAA-covered patient identifiers were removed. Western Institutional Review Board determined the study to be exempt from the Office for Human Research Protections Regulations for the Protection of Human Subjects (45 CFR 46) under category 4. Retrospective data analysis of anonymized data exempted the study from the requirement to receive consent from patients.