Acknowledgements
This work was financially supported by the National Key Research Development Program of China (No. 2019YFA0904800), the National Natural Science Foundation of China (No. 21276081) and the National Scientific and Technological Major Special Project (Significant Creation of New drugs, No. 2011ZX09203-001-03). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
We thank Kuipu Zhang from East China Universtiy of Science and Technology for help with graphics and Robin Dorau from Technical University of Denmark for constructive criticism of the manuscript.