Acknowledgements
This work was financially supported by the National Key Research
Development Program of China (No. 2019YFA0904800), the National Natural
Science Foundation of China (No. 21276081) and the National Scientific
and Technological Major Special Project (Significant Creation of New
drugs, No.
2011ZX09203-001-03).
The funders had no role in study design, data collection and
interpretation, or the decision to submit the work for publication.
We thank Kuipu Zhang from East China Universtiy of Science and
Technology for help with graphics and Robin Dorau from Technical
University of Denmark for constructive criticism of the manuscript.