4. Conclusion
In summary, the OHH NPs nanoplatform was fabricated for
antibiotic-photothermal ablation of K.pneumoniae bacteria. The
integrated nanoplatform could efficiently adhere ontoK.pneumoniae bacteria and damage bacterial membrane by subsequent
PTT under NIR irradiation. The exploration of the antibacterial
mechanism shows that the powerful bactericidal ability of the
cooperative system and the inhibition of drug resistance can be
attributed to the generation of ROS, which destroys the integrity of
cell membranes, reduces ATP and disrupts bacterial metabolism. The
outstanding bactericidal capability of the OHH NPs nanoplatform under
NIR irradiation was also confirmed by an in vivoK.pneumoniae -infected model on mice. OHH NPs nanoplatform
combined with antibiotic-photothermal therapy can be considered as a
very promising strategy to effectively eliminate bacteria and inhibit
the development of drug resistance.