Ethical Consideration
The ethic committee of institution (Azienda Ospedaliera Universitaria, Policlinco Umberto I, Università “La Sapienza”, Rome , Italy ) approved the study (ID: 5435, CE, SAPIENZA). All patients gave written informed consent to the use of their clinical and serological data in this study. The whole study was conducted according to the Declaration of Helsinki, as revised in 2013.