Ethical Consideration
The ethic committee of institution (Azienda Ospedaliera Universitaria,
Policlinco Umberto I, Università “La Sapienza”, Rome , Italy )
approved the study (ID: 5435, CE, SAPIENZA). All patients gave written
informed consent to the use of their clinical and serological data in
this study. The whole study was conducted according to the Declaration
of Helsinki, as revised in 2013.