Figure 2:
Longitudinal Cytokine analysis and Cellular composition in SLE SF (A) Longitudinal cytokine analysis of SLE-SF. Change of medication and the timepoint obtaining SFMC are indicated. (B) Proportions of cell subsets in SF and matched PB. B-cell subsets: plasmablasts (CD27++CD38++); naïve (IgD+CD27-), double positive (IgD+CD27+), memory (IgD-CD27+), double negative (DN, IgD-CD27-). Monocyte subsets: non-classical (CD14-C16+), intermediate (CD14+C16-+), classical (CD14+C16-) and non-monocytes (CD14-CD16-). Dendritic Cell subsets: classical DC (cDC, CD11c+), cDC1 (CD11c+CD1c+), cDC2 (CD11c+CD141+) and pDC (CD11c-CD123+CD303+). Frequencies <4% are not displayed. (C) tSNE clustering of CD3+ cells from the two T-cell panels (Supplementary Table S4) and CD4+ and CD8 T-cell subsets in paired PB and SF (n=1)