Figure 2:
Longitudinal Cytokine analysis and Cellular composition in SLE
SF (A) Longitudinal cytokine analysis of SLE-SF. Change of medication
and the timepoint obtaining SFMC are indicated. (B) Proportions of cell
subsets in SF and matched PB. B-cell subsets: plasmablasts
(CD27++CD38++); naïve (IgD+CD27-), double positive (IgD+CD27+), memory
(IgD-CD27+), double negative (DN, IgD-CD27-). Monocyte subsets:
non-classical (CD14-C16+), intermediate (CD14+C16-+), classical
(CD14+C16-) and non-monocytes (CD14-CD16-). Dendritic Cell subsets:
classical DC (cDC, CD11c+), cDC1 (CD11c+CD1c+), cDC2 (CD11c+CD141+) and
pDC (CD11c-CD123+CD303+). Frequencies <4% are not displayed.
(C) tSNE clustering of CD3+ cells from the two T-cell panels
(Supplementary Table S4) and CD4+ and CD8 T-cell subsets in paired PB
and SF (n=1)