Acknowledgements
The authors would like to acknowledge Process Development Analytics for their contributions to this work. The authors also thank Dr. Magfur Alam, Dr. Dhanuka Wasalathanthri and Dana Brandariz for providing thorough review and invaluable comments. All financial support was provided by BMS: T.R., Z.T., V.E., A.L., S.G., and Z.L. are employees of BMS. The authors have no conflicts of interest to declare.