Figure 4: Curve fitting forecasts amino acid profiles . (A) Bioprocess data from days 4-7 are used to estimate tyrosine consumption rates (empty circles). These estimations are used to parameterize a sigmoid curve (line; see Methods, equation 3) that describes the consumption profile for the entire culture duration. This predicted time-course consumption profile agreed well with experimental measurements (filled circle). Time-course profiles of other amino acids are provided in Supplementary Figures. (B) Overall, model predictions and experimental measurements agreed fairly well for all amino acids (Spearman ρ = 0.54).