Study design and population
This prospective, observational study is based on a clinical study conducted at the between November 2013 and April 2016. The study participation was open for anyone visiting the hospital interested to participate in a clinical study.
There were no specific inclusion criteria. Exclusion criteria were night-work employment and intake of medication with a potential effect on urine output (such as diuretics, desmopressin, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists and non-steroidal anti-inflammatory drugs).