Figure legends
Figure 1 . The profiles of biomass, cell viability, living cells
(A) and residual glucose, ethanol, glycerol (B) as a sinusoidal function
with different phases (0 or π) in an oscillation period. P1-5 represent
five sampling points at the beginning (P1), bottom (P2), middle (P3),
top (P4), and end (P5) of the biomass oscillation period.
Figure 2 . Statistical analysis for differentially expressed
genes (DEGs) according to log2 ratio≥1 or ≤-1.
Comparison between adjacent samples (left) and samples P2-5 to P1
(right).
Figure 3 . Integrated view of metabolome and transcriptome in
central carbon metabolism pathways for neighboring samples. The gene
expression and metabolite pool were marked as squares and circles,
respectively. Red, green, and yellow represented up-regulation,
down-regulation and no significant changes between two samples. Refer to
Figure S3 for more detail of the metabolites and enzymes shown.
Figure 4 . The concentrations of main intracellular metabolites
(A) and the gene expression level (B) as a function of time in an
oscillation period, including the main pathways of carbon metabolism,
such as EMP (Red), Ethanol production (Pink), TCA (Yellow), Glycerol
generation (Purple), Trehalose generation (Green), PPP (Blue) and other
related factors (Black).
Figure 5. The expression level of genes related to stress
responses.
Figure 6. Analysis of DEGs in the synthesis of ribosome
subunits. The DEGs between (A) P2/P1, (B) P3/P2, (C) P4/P3, (D) P5/P4,
and (E) the sin curve of DEGs total counts.