5 References

Baek, J. H., Zhou, Y., Harris, D. R., Schaer, D. J., Palmer, A. F., & Buehler, P. W. (2012). Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a Guinea pig model.Toxicological Sciences , 127 (2), 567–581. https://doi.org/10.1093/toxsci/kfs109
Belcher, D. A., Cuddington, C. T., Martindale, E. L., Pires, I. S., & Palmer, A. F. (2020). Controlled Polymerization and Ultrafiltration Increase the Consistency of Polymerized Hemoglobin for Use as an Oxygen Carrier. Bioconjugate Chemistry . https://doi.org/10.1021/acs.bioconjchem.9b00766
Belcher, D. A., Ju, J. A., Baek, J. H., Yalamanoglu, A., Buehler, P. W., Gilkes, D. M., & Palmer, A. F. (2018). The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study. PLoS ONE ,13 (2). https://doi.org/10.1371/journal.pone.0191275
Bonaventura, C., Henkens, R., Alayash, A. I., & Crumbliss, A. L. (2007). Allosteric effects on oxidative and nitrosative reactions of cell-free hemoglobins. IUBMB Life , Vol. 59, pp. 498–505. https://doi.org/10.1080/15216540601188546
Buehler, P. W., Boykins, R. A., Jia, Y., Norris, S., Freedberg, D. I., & Alayash, A. I. (2005). Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions.Analytical Chemistry , 77 (11), 3466–3478. https://doi.org/10.1021/ac050064y
Cabrales, P., Sun, G., Zhou, Y., Harris, D. R., Tsai, A. G., Intaglietta, M., & Palmer, A. F. (2009). Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction. Journal of Applied Physiology , 107 (5), 1548–1558. https://doi.org/10.1152/japplphysiol.00622.2009
Cabrales, P., Tsai, A. G., & Intaglietta, M. (2008). Balance between vasoconstriction and enhanced oxygen delivery. Transfusion ,48 (10), 2087–2095. https://doi.org/10.1111/j.1537-2995.2008.01834.x
Cabrales, P., Zhou, Y., Harris, D. R., & Palmer, A. F. (2010). Tissue oxygenation after exchange transfusion with ultrahigh-molecular- weight tense- and relaxed-state polymerized bovine hemoglobins. American Journal of Physiology - Heart and Circulatory Physiology ,298 (3). https://doi.org/10.1152/ajpheart.01022.2009
Chen, W. T., Chen, Y. C., Liou, H. H., & Chao, C. Y. (2015). Structural basis for cooperative oxygen binding and bracelet-assisted assembly of Lumbricus terrestris hemoglobin. Scientific Reports , 5 . https://doi.org/10.1038/srep09494
Cheng, D. C. H., Mazer, C. D., Martineau, R., Ralph-Edwards, A., Karski, J., Robblee, J., … Vuylsteke, A. (2004). A phase II dose-response study of hemoglobin raffimer (Hemolink) in elective coronary artery bypass surgery. Journal of Thoracic and Cardiovascular Surgery ,127 (1), 79–86. https://doi.org/10.1016/j.jtcvs.2003.08.024
Cuddington, C., Moses, S., Belcher, D., Ramesh, N., & Palmer, A. (2020). Use of Next‐Generation Polymerized Human Hemoglobins in Hepatic Bioreactor Simulations. Biotechnology Progress . https://doi.org/10.1002/btpr.2958
Day, T. K. (2003). Current development and use of hemoglobin-based oxygen-carrying (HBOC) solutions. Journal of Veterinary Emergency and Critical Care , Vol. 13, pp. 77–93. https://doi.org/10.1046/j.1435-6935.2003.00084.x
Drabkin, DL ; Austin, J. (1935). Spectrophotometric studies II. Preparations from washed blood cells; nitric oxide hemoglobin and sulfhemoglobin. The Journal of Biological Chemistry ,112 (1), 51–65. https://doi.org/0021-9258
Elmer, J., Harris, D., & Palmer, A. F. (2011). Purification of hemoglobin from red blood cells using tangential flow filtration and immobilized metal ion affinity chromatography. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , 879 (2), 131–138. https://doi.org/10.1016/j.jchromb.2010.11.021
Etzerodt, A., & Moestrup, S. K. (2013). CD163 and inflammation: Biological, diagnostic, and therapeutic aspects. Antioxidants and Redox Signaling , Vol. 18, pp. 2352–2363. https://doi.org/10.1089/ars.2012.4834
Gertz, M. A., & Kyle, R. A. (1995). Hyperviscosity Syndrome.Journal of Intensive Care Medicine , 10 (3), 128–141. https://doi.org/10.1177/088506669501000304
Gould, S. A., Moore, E. E., Hoyt, D. B., Burch, J. M., Haenel, J. B., Garcia, J., … Moss, G. S. (1998). The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery. Journal of the American College of Surgeons ,187 (2), 113–120. https://doi.org/10.1016/S1072-7515(98)00095-7
Gould, S. A., & Moss, G. S. (1996). Clinical development of human polymerized hemoglobin as a blood substitute. World Journal of Surgery , Vol. 20, pp. 1200–1207. https://doi.org/10.1007/s002689900183
J.S., J., M., M., & J.C., L. (2008). HBOC-201, hemoglobin glutamer-250 (bovine), Hemopure (Biopure Corporation). Expert Opinion on Biological Therapy , Vol. 8, pp. 1425–1433. Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed8&NEWS=N&AN=2008455091
Jahr, J. S., MacKenzie, C., Pearce, L. B., Pitman, A., & Greenburg, A. G. (2008). HBOC-201 as an alternative to blood transfusion: Efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery. Journal of Trauma - Injury, Infection and Critical Care , 64 (6), 1484–1497. https://doi.org/10.1097/TA.0b013e318173a93f
Jia, Y., Ramasamy, S., Wood, F., Alayash, A. I., & Rifkind, J. M. (2004). Cross-linking with O-raffinose lowers oxygen affinity and stabilizes haemoglobin in a non-cooperative T-state conformation.Biochemical Journal , 384 (2), 367–375. https://doi.org/10.1042/BJ20040612
Levy, J. H., Goodnough, L. T., Greilich, P. E., Parr, G. V. S., Stewart, R. W., Gratz, I., … Vlahakes, G. J. (2002). Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: Results of a randomized, double-blind trial. Journal of Thoracic and Cardiovascular Surgery ,124 (1), 35–42. https://doi.org/10.1067/mtc.2002.121505
Leytin, V., Mazer, D., Mody, M., Garvey, B., & Freedman, J. (2003). Hemolinktm, an o-raffinose cross-linked haemoglobin-based oxygen carrier, does not affect activation and function of human platelets in whole blood in vitro. British Journal of Haematology ,120 (3), 535–541. https://doi.org/10.1046/j.1365-2141.2003.04068.x
Liu, D., Mori, A., & Huang, L. (1992). Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes. BBA - Biomembranes , 1104 (1), 95–101. https://doi.org/10.1016/0005-2736(92)90136-A
Lou Carmichael, F. J., Ali, A. C. Y., Campbell, J. A., Langlois, S. F., Biro, G. P., Willan, A. R., … Gerson Greenburg, A. (2000). A phase I study of oxidized raffinose cross-linked human hemoglobin.Critical Care Medicine , 28 (7), 2283–2292. https://doi.org/10.1097/00003246-200007000-00017
Marret, E., Bonnin, P., Mazoyer, E., Riou, B., Jacobs, T., Coriat, P., & Samama, C. M. (2004). The Effects of a Polymerized Bovine-Derived Hemoglobin Solution in a Rabbit Model of Arterial Thrombosis and Bleeding. Anesthesia and Analgesia , 98 (3), 604–610. https://doi.org/10.1213/01.ANE.0000099366.73625.DD
Meng, F., Kassa, T., Jana, S., Wood, F., Zhang, X., Jia, Y., … Alayash, A. I. (2018a). Comprehensive Biochemical and Biophysical Characterization of Hemoglobin-Based Oxygen Carrier Therapeutics: All HBOCs Are Not Created Equally [Research-article]. Bioconjugate Chemistry , 29 (5), 1560–1575. https://doi.org/10.1021/acs.bioconjchem.8b00093
Meng, F., Kassa, T., Jana, S., Wood, F., Zhang, X., Jia, Y., … Alayash, A. I. (2018b). Comprehensive Biochemical and Biophysical Characterization of Hemoglobin-Based Oxygen Carrier Therapeutics: All HBOCs Are Not Created Equally. Bioconjugate Chemistry ,29 (5), 1560–1575. https://doi.org/10.1021/acs.bioconjchem.8b00093
Moore, E. E., Moore, F. A., Fabian, T. C., Bernard, A. C., Fulda, G. J., Hoyt, D. B., … Gould, S. A. (2009). Human Polymerized Hemoglobin for the Treatment of Hemorrhagic Shock when Blood Is Unavailable: The USA Multicenter Trial. Journal of the American College of Surgeons , 208 (1), 1–13. https://doi.org/10.1016/j.jamcollsurg.2008.09.023
Moradi, S., Jahanian-Najafabadi, A., & Roudkenar, M. H. (2016). Artificial blood substitutes: First steps on the long route to clinical utility. Clinical Medicine Insights: Blood Disorders , 9 , 33–41. https://doi.org/10.4137/CMBD.S38461
Napolitano, L. M. (2009a). Hemoglobin-based Oxygen Carriers : First, Second or Third Generation? Human or Bovine? Where are we Now? Hemoglobin-based oxygen carrier HBOC Intensive care Critical care Blood transfusion Hemoglobin. Crit Care Clin , 25 , 279–301. https://doi.org/10.1016/j.ccc.2009.01.003
Napolitano, L. M. (2009b). Hemoglobin-based Oxygen Carriers: First, Second or Third Generation? Human or Bovine? Where are we Now?Critical Care Clinics , Vol. 25, pp. 279–301. https://doi.org/10.1016/j.ccc.2009.01.003
Palmer, A. F., & Intaglietta, M. (2014). Blood Substitutes.Annual Review of Biomedical Engineering , 16 (1), 77–101. https://doi.org/10.1146/annurev-bioeng-071813-104950
Palmer, A. F., Sun, G., & Harris, D. R. (2009). Tangential flow filtration of hemoglobin. Biotechnology Progress , 25 (1), 189–199. https://doi.org/10.1002/btpr.119
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987). Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature , 327 (6122), 524–526. https://doi.org/10.1038/327524a0
Pearce, L. B., Gawryl, M. S., Rentko, V. T., Moon-Massat, P. F., & Rausch, C. W. (2006). HBOC-201 (Hemoglobin Glutamer-250 (Bovine), Hemopure®). Clinical studies. In Blood Substitutes (pp. 437–450). https://doi.org/10.1016/B978-012759760-7/50047-0
Poli De Figueiredo, L. F., Mathru, M., Solanki, D., Macdonald, V. W., Hess, J., & Kramer, G. C. (1997). Pulmonary hypertension and systemic vasoconstriction may offset the benefits of acellular hemoglobin blood substitutes. Journal of Trauma - Injury, Infection and Critical Care , 42 (5), 847–856. https://doi.org/10.1097/00005373-199705000-00015
Rameez, S., Guzman, N., Banerjee, U., Fontes, J., Paulaitis, M. E., Palmer, A. F., … Honavar, J. (2012). Encapsulation of hemoglobin inside liposomes surface conjugated with poly(ethylene glycol) attenuates their reactions with gaseous ligands and regulates nitric oxide dependent vasodilation. Biotechnology Progress ,28 (3), 636–645. https://doi.org/10.1002/btpr.1532
Rameez, S., & Palmer, A. F. (2011). Simple method for preparing poly(ethylene glycol)-surface-conjugated liposome-encapsulated hemoglobins: Physicochemical properties, long-term storage stability, and their reactions with O2, CO, and NO. Langmuir , 27 (14), 8829–8840. https://doi.org/10.1021/la201246m
Rice, J., Philbin, N., Light, R., Arnaud, F., Steinbach, T., McGwin, G., … Freilich, D. (2008). The effects of decreasing low-molecular weight hemoglobin components of hemoglobin-based oxygen carriers in swine with hemorrhagic shock. Journal of Trauma - Injury, Infection and Critical Care , 64 (5), 1240–1257. https://doi.org/10.1097/TA.0b013e318058245e
Sakai, H., Hara, H., Yuasa, M., Tsai, A. G., Takeoka, S., Tsuchida, E., & Intaglietta, M. (2000). Molecular dimensions of Hb-based O2 carriers determine constriction of resistance arteries and hypertension.American Journal of Physiology - Heart and Circulatory Physiology , 279 (3 48-3). https://doi.org/10.1152/ajpheart.2000.279.3.h908
Sehgal, L. R., Gould, S. A., Rosen, A. L., Sehgal, H. L., & Moss, G. S. (1984). Polymerized pyridoxylated hemoglobin: A red cell substitute with normal oxygen capacity. Surgery , 95 (4), 433–438.
Tsai, A. G., Cabrales, P., Manjula, B. N., Acharya, S. A., Winslow, R. M., & Intaglietta, M. (2006). Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers. Blood , 108 (10), 3603–3610. https://doi.org/10.1182/blood-2006-02-005272
Tsuruga, M., Matsuoka, A., Hachimori, A., Sugawara, Y., & Shikama, K. (1998). The molecular mechanism of autoxidation for human oxyhemoglobin. Tilting of the distal histidine causes nonequivalent oxidation in the β chain. Journal of Biological Chemistry , 273 (15), 8607–8615. https://doi.org/10.1074/jbc.273.15.8607
Zhang, N., Jia, Y., Chen, G., Cabrales, P., & Palmer, A. F. (2011). Biophysical properties and oxygenation potential of high-molecular-weight glutaraldehyde-polymerized human hemoglobins maintained in the tense and relaxed quaternary states. Tissue Engineering - Part A , 17 (7–8), 927–940. https://doi.org/10.1089/ten.tea.2010.0353
Zhou, Y. (2011). Synthesis and Biophysical Characterization of Polymerized Hemoglobin Dispersions of Varying Size and Oxygen Affinity as Potential Oxygen Carriers for use in Transfusion Medicine.ProQuest Dissertations and Theses , Ph.D. Retrieved from http://search.proquest.com/docview/920005184?accountid=8359
Zhou, Y., Jia, Y., Buehler, P. W., Chen, G., Cabrales, P., & Palmer, A. F. (2011). Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity. Biotechnology Progress , 27 (4), 1172–1184. https://doi.org/10.1002/btpr.624