Figure captions
Figure 1 . The renin-angiotensin and the kallikrein-kinin systems in the regulation of blood pressure. The intricate interplay between these two systems, dependent on the ACE, is the basis of the control of blood pressure. While the renin-angiotensin mechanism leads to vasoconstriction and water retention, increasing blood pressure, the kallikrein-kinin system has opposite effects by promoting vasodilation.
Figure 2. Overview of cloning and expression of ACEIp-coding synthetic genes in plants and algae. Three main cloning strategies are used: 1) tandem repeats of a target ACEIp sequence; 2) introduction of the ACEIp in the hypervariable region of storage proteins, and the 3) assembly of ACEI polypeptides with others bioactive peptides. These strategies can be applied in different plant/algae expression platforms, such as whole transgenic plants/algae, transplastomic plants/algae and plant/algae cell suspension cultures. The resulting ACEIp-enriched plants/algae can be used for direct human consumption (direct oral delivery) or processed by hydrolysis and purified to be used as food supplements. Images used are from Adobe Stock.