References
Alonso H, Bliznyuk AA, Gready JE. 2006. Combining docking and molecular
dynamic simulations in drug design. Med. Res. Rev.26 :531–568.
Aluko RE. 2015. Antihypertensive Peptides from Food Proteins.Annu. Rev. Food Sci. Technol. 6 :235–262.
Asoodeh A, Yazdi MM, Chamani J. 2012. Purification and characterisation
of angiotensin I converting enzyme inhibitory peptides from lysozyme
hydrolysates. Food Chem. 131 :291–295.
Auwal SM, Zarei M, Tan CP, Basri M, Saari N. 2017. Improved in vivo
efficacy of anti-hypertensive biopeptides encapsulated in chitosan
nanoparticles fabricated by ionotropic gelation on spontaneously
hypertensive rats. Nanomaterials 7 .
Balti R, Bougatef A, Sila A, Guillochon D, Dhulster P, Nedjar-Arroume N.
2015. Nine novel angiotensin I-converting enzyme (ACE) inhibitory
peptides from cuttlefish (Sepia officinalis) muscle protein hydrolysates
and antihypertensive effect of the potent active peptide in
spontaneously hypertensive rats. Food Chem.170 :519–525.
http://www.sciencedirect.com/science/article/pii/S0308814613004366.
Berryman LY. 2000. Pharmacotherapy Handbook. 2nd Edition. Ann.
Pharmacother. Vol. 34 1490–1490 p.
Brunton L, Lazo J, Parker K. 2005. Goodman & Gilman’s the
pharmacological basis of therapeutics 13th ed. McGraw-Hill Education.
Burrello J, Monticone S, Buffolo F, Tetti M, Veglio F, Williams TA,
Mulatero P. 2017. Is there a role for genomics in the management of
hypertension? Int. J. Mol. Sci. 18 :1131.
Campos-Quevedo N, Rosales-Mendoza S, Paz-Maldonado LMT, Martínez-Salgado
L, Guevara-Arauza JC, Soria-Guerra RE. 2013. Production of milk-derived
bioactive peptides as precursor chimeric proteins in chloroplasts of
Chlamydomonas reinhardtii. Plant Cell, Tissue Organ Cult.113 :217–225. http://dx.doi.org/10.1007/s11240-012-0261-3.
Carretero OA, Oparil S. 2000. Essential hypertension. Part I: Definition
and etiology. Circulation 101 :329–335.
Castellano P, Aristoy MC, Sentandreu MÁ, Vignolo G, Toldrá F. 2013.
Peptides with angiotensin I converting enzyme (ACE) inhibitory activity
generated from porcine skeletal muscle proteins by the action of
meat-borne Lactobacillus. J. Proteomics 89 :183–190.
Castro-Martínez C, Luna-Suárez S, Paredes-López O. 2012. Overexpression
of a modified protein from amaranth seed in Escherichia coli and effect
of environmental conditions on the protein expression. J.
Biotechnol. 158 :59–67.
http://www.sciencedirect.com/science/article/pii/S0168165611006687.
Chen Y, Wang Z, Chen X, Liu Y, Zhang H, Sun T. 2010. Identification of
angiotensin I-converting enzyme inhibitory peptides from koumiss, a
traditional fermented mare’s milk. J. Dairy Sci.93 :884–892.
Clark MA, Harvey RA, Finkel R, Rey JA, Whalen K. 2011. Pharmacology.
Wolters Kluwer Health. Illustrated Reviews.
Donkor ON, Henriksson A, Vasiljevic T, Shah NP. 2005. Probiotic Strains
as Starter Cultures Improve Angiotensin-converting Enzyme Inhibitory
Activity in Soy Yogurt. J. Food Sci. 70 :m375–m381.
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2621.2005.tb11522.x.
Duan X, Wu F, Li M, Yang N, Wu C, Jin Y, Yang J, Jin Z, Xu X. 2014.
Naturally occurring angiotensin I-converting enzyme inhibitory peptide
from a fertilized egg and its inhibitory mechanism. J. Agric. Food
Chem. 62 :5500–5506.
Egan BM. 2007. Combination therapy with an angiotensin-converting enzyme
inhibitor and a calcium channel blocker. J. Clin. Hypertens.
(Greenwich). 9 :783–789.
Ehret GB, Caulfield MJ. 2013. Genes for blood pressure: An opportunity
to understand hypertension. Eur. Heart J. 34 :951–961.
Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T,
Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V,
Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M,
Bouatia-Naji N, Kristiansson K, Shah S, Kleber ME, Guo X, Lyytikäinen
LP, Fava C, Eriksson N, Nolte IM, Magnusson PK, Salfati EL, Rallidis LS,
Theusch E, Smith AJP, Folkersen L, Witkowska K, Pers TH, Joehanes R, Kim
SK, Lataniotis L, Jansen R, Johnson AD, Warren H, Kim YJ, Zhao W, Wu Y,
Tayo BO, Bochud M, Absher D, Adair LS, Amin N, Arking DE, Axelsson T,
Baldassarre D, Balkau B, Bandinelli S, Barnes MR, Barroso I, Bevan S,
Bis JC, Bjornsdottir G, Boehnke M, Boerwinkle E, Bonnycastle LL, Boomsma
DI, Bornstein SR, Brown MJ, Burnier M, Cabrera CP, Chambers JC, Chang
IS, Cheng CY, Chines PS, Chung RH, Collins FS, Connell JM, Döring A,
Dallongeville J, Danesh J, De Faire U, Delgado G, Dominiczak AF, Doney
ASF, Drenos F, Edkins S, Eicher JD, Elosua R, Enroth S, Erdmann J,
Eriksson P, Esko T, Evangelou E, Evans A, Fall T, Farrall M, Felix JF,
Ferrières J, Ferrucci L, Fornage M, Forrester T, Franceschini N, Franco
OH, Franco-Cereceda A, Fraser RM, Ganesh SK, Gao H, Gertow K, Gianfagna
F, Gigante B, Giulianini F, Goel A, Goodall AH, Goodarzi MO, Gorski M,
Gräßler J, Groves CJ, Gudnason V, Gyllensten U, Hallmans G, Hartikainen
AL, Hassinen M, Havulinna AS, Hayward C, Hercberg S, Herzig KH, Hicks
AA, Hingorani AD, Hirschhorn JN, Hofman A, Holmen J, Holmen OL, Hottenga
JJ, Howard P, Hsiung CA, Hunt SC, Ikram MA, Illig T, Iribarren C, Jensen
RA, Kähönen M, Kang HM, Kathiresan S, Keating BJ, Khaw KT, Kim YK, Kim
E, Kivimaki M, Klopp N, Kolovou G, Komulainen P, Kooner JS, Kosova G,
Krauss RM, Kuh D, Kutalik Z, Kuusisto J, Kvaløy K, Lakka TA, Lee NR, Lee
I Te, Lee WJ, Levy D, Li X, Liang KW, Lin H, Lin L, Lindström J, Lobbens
S, Männistö S, Müller G, Müller-Nurasyid M, Mach F, Markus HS, Marouli
E, McCarthy MI, McKenzie CA, Meneton P, Menni C, Metspalu A, Mijatovic
V, Moilanen L, Montasser ME, Morris AD, Morrison AC, Mulas A, Nagaraja
R, Narisu N, Nikus K, O’Donnell CJ, O’Reilly PF, Ong KK, Paccaud F,
Palmer CD, Parsa A, Pedersen NL, Penninx BW, Perola M, Peters A, Poulter
N, Pramstaller PP, Psaty BM, Quertermous T, Rao DC, Rasheed A, Rayner
NW, Renström F, Rettig R, Rice KM, Roberts R, Rose LM, Rossouw J, Samani
NJ, Sanna S, Saramies J, Schunkert H, Sebert S, Sheu WHH, Shin YA, Sim
X, Smit JH, Smith A V., Sosa MX, Spector TD, Stančáková A, Stanton A V.,
Stirrups KE, Stringham HM, Sundstrom J, Swift AJ, Syvänen AC, Tai ES,
Tanaka T, Tarasov K V., Teumer A, Thorsteinsdottir U, Tobin MD, Tremoli
E, Uitterlinden AG, Uusitupa M, Vaez A, Vaidya D, Van Duijn CM, Van
Iperen EPA, Vasan RS, Verwoert GC, Virtamo J, Vitart V, Voight BF,
Vollenweider P, Wagner A, Wain L V., Wareham NJ, Watkins H, Weder AB,
Westra HJ, Wilks R, Wilsgaard T, Wilson JF, Wong TY, Yang TP, Yao J,
Yengo L, Zhang W, Zhao JH, Zhu X, Bovet P, Cooper RS, Mohlke KL,
Saleheen D, Lee JY, Elliott P, Gierman HJ, Willer CJ, Franke L, Hovingh
GK, Taylor KD, Dedoussis G, Sever P, Wong A, Lind L, Assimes TL,
Njølstad I, Schwarz PEH, Langenberg C, Snieder H, Caulfield MJ, Melander
O, Laakso M, Saltevo J, Rauramaa R, Tuomilehto J, Ingelsson E, Lehtimäki
T, Hveem K, Palmas W, März W, Kumari M, Salomaa V, Chen YDI, Rotter JI,
Froguel P, Jarvelin MR, Lakatta EG, Kuulasmaa K, Franks PW, Hamsten A,
Wichmann HE, Palmer CNA, Stefansson K, Ridker PM, Loos RJF, Chakravarti
A, Deloukas P, Morris AP, Newton-Cheh C, Munroe PB. 2016. The genetics
of blood pressure regulation and its target organs from association
studies in 342,415 individuals. Nat. Genet.48 :1171–1184.
Fida HM, Kumada Y, Terashima M, Katsuda T, Katoh S. 2009. Tandem
multimer expression of angiotensin I-converting enzyme inhibitory
peptide in Escherichia coli. Biotechnol J 4 :1345–1356.
Fletcher SP, Muto M, Mayfield SP. 2007. Optimization of Recombinant
Protein Expression in the Chloroplasts of Green Algae. In: León, R,
Galván, A, Fernández, E, editors. Transgenic Microalgae as Green
Cell Factories . New York, NY: Springer New York, pp. 90–98.
http://dx.doi.org/10.1007/978-0-387-75532-8_8.
Fujita H, Yoshikawa M. 1999. LKPNM: a prodrug-type ACE-inhibitory
peptide derived from fish protein. Immunopharmacology44 :123–127.
http://www.sciencedirect.com/science/article/pii/S0162310999001186.
Geng X, Tian G, Zhang W, Zhao Y, Zhao L, Ryu M, Wang H, Ng TB. 2015.
Isolation of an Angiotensin I-Converting Enzyme Inhibitory Protein with
Antihypertensive Effect in Spontaneously Hypertensive Rats from the
Edible Wild Mushroom Leucopaxillus tricolor. Molecules20 :10141–10153. http://www.mdpi.com/1420-3049/20/6/10141/pdf.
Germán-Báez L, Cruz-Mendívil A, Medina-Godoy S, Milán-Carrillo J,
Reyes-Moreno C, Valdez-Ortiz A. 2014. Expression of an engineered
acidic-subunit 11S globulin of amaranth carrying the antihypertensive
peptides VY, in transgenic tomato fruits. Plant Cell, Tissue Organ
Cult. 118 :305–312.
http://dx.doi.org/10.1007/s11240-014-0483-7.
Ghanbari R, Zarei M, Ebrahimpour A, Abdul-Hamid A, Ismail A, Saari N.
2015. Angiotensin-I Converting Enzyme (ACE) Inhibitory and Anti-Oxidant
Activities of Sea Cucumber (Actinopyga lecanora) Hydrolysates.Int. J. Mol. Sci. 16 :28870–28885.
http://www.mdpi.com/1422-0067/16/12/26140/pdf.
Gomes C, Oliveira F, Isabel Vieira S, Sofia Duque A. 2019. Prospects for
the Production of Recombinant Therapeutic Proteins and Peptides in
Plants: Special Focus on Angiotensin I-Converting Enzyme Inhibitory
(ACEI) Peptides. In: . Genet. Eng. [Working Title] .
IntechOpen.
https://www.intechopen.com/online-first/prospects-for-the-production-of-recombinant-therapeutic-proteins-and-peptides-in-plants-special-focu.
González-Ortega O, López-Limón AR, Morales-Domínguez JF, Soria-Guerra
RE. 2015. Production and purification of recombinant hypocholesterolemic
peptides. Biotechnol. Lett. 37 :41–54.
http://dx.doi.org/10.1007/s10529-014-1657-4.
Gouveia M, Xia K, Colón W, Vieira SI, Ribeiro F. 2017. Protein
aggregation, cardiovascular diseases, and exercise training: Where do we
stand? Ageing Res. Rev. 40 :1–10.
Hartmann R, Meisel H. 2007. Food-derived peptides with biological
activity: from research to food applications. Curr. Opin.
Biotechnol. 18 :163–169.
Hasan F, Kumada Y, Hashimoto N, Katsuda T, Terashima M, Katoh S. 2006.
Fragmentation of angiotensin-I converting enzyme inhibitory peptides
from bonito meat under intestinal digestion conditions and their
characterization. Food Bioprod. Process. 84 :135–138.
Hayes M, Tiwari BK. 2015. Bioactive carbohydrates and peptides in foods:
An overview of sources, downstream processing steps and associated
bioactivities. Int. J. Mol. Sci. 16 :22485–22508.
http://www.mdpi.com/1422-0067/16/9/22485/pdf.
Huang GQ, Xiao JX, Hao LQ, Yang J. 2017. Microencapsulation of an
Angiotensin I-Converting Enzyme Inhibitory Peptide VLPVP by Membrane
Emulsification. Food Bioprocess Technol. 10 :2005–2012.
Huang L, Ma H, Li Y, Li S. 2012. Antihypertensive activity of
recombinant peptide IYPR expressed in Escherichia coli as inclusion
bodies. Protein Expr. Purif. 83 :15–20.
http://www.sciencedirect.com/science/article/pii/S1046592812000538.
Iwaniak A, Minkiewicz P, Darewicz M. 2014. Food-originating ACE
Inhibitors, including antihypertensive peptides, as preventive food
components in blood pressure reduction. Compr. Rev. Food Sci. Food
Saf. 13 :114–134.
Iwaniak A, Minkiewicz P, Darewicz M, Hrynkiewicz M. 2016a. Food
protein-originating peptides as tastants - Physiological, technological,
sensory, and bioinformatic approaches. Food Res. Int.89 :27–38.
Iwaniak A, Minkiewicz P, Darewicz M, Sieniawski K, Starowicz P. 2016b.
BIOPEP database of sensory peptides and amino acids. Food Res.
Int. 85 :155–161.
Jafar TH, Stark PC, Schmid CH, Landa M, Maschio G, De Jong PE, De Zeeuw
D, Shahinfar S, Toto R, Levey AS. 2003. Progression of Chronic Kidney
Disease: The Role of Blood Pressure Control, Proteinuria, and
Angiotensin-Converting Enzyme Inhibition. A Patient-Level Meta-Analysis.Ann. Intern. Med. 139 :244–252.
Jakubczyk A, Baraniak B. 2014. Angiotensin i Converting Enzyme
Inhibitory Peptides Obtained after in Vitro Hydrolysis of Pea (Pisum
sativum var. Bajka) Globulins. Biomed Res. Int.2014 :438459.
Jeong DW, Shin DS, Ahn CW, Song IS, Lee HJ. 2007. Expression of
antihypertensive peptide, His-His-Leu, as tandem repeats in Escherichia
coli. J. Microbiol. Biotechnol. 17 :952–959.
Jimsheena VK, Gowda LR. 2010. Arachin derived peptides as selective
angiotensin I-converting enzyme ( ACE) inhibitors: Structure-activity
relationship. Peptides 31 :1165–1176.
Kamath BL. 1990. Applied Therapeutics. The Clinical Use of Drugs.J. Pharm. Sci. Wolters Kluwer/Lippincott Williams & Wilkins.
Vol. 79 279 p.
Kasper DL, Fauci AS, Hauser SL, Longo DL. 2015. Harrison’s PRINCIPLES OF
INTERNAL MEDICINE.
Kelly JG, O’Malley K. 1990. Clinical Pharmacokinetics of the Newer ACE
Inhibitors: A Review. Clin. Pharmacokinet. 19 :177–196.
Kim JM, Jang SA, Yu BJ, Sung BH, Cho JH, Kim SC. 2008. High-level
expression of an antimicrobial peptide histonin as a natural form by
multimerization and furin-mediated cleavage. Appl. Microbiol.
Biotechnol. 78 :123–130.
http://dx.doi.org/10.1007/s00253-007-1273-5.
Lee JK, Hong S, Jeon JK, Kim SK, Byun HG. 2009. Purification and
characterization of angiotensin I converting enzyme inhibitory peptides
from the rotifer, Brachionus rotundiformis. Bioresour. Technol.100 :5255–5259.
Lee SH, Qian ZJ, Kim SK. 2010. A novel angiotensin I converting enzyme
inhibitory peptide from tuna frame protein hydrolysate and its
antihypertensive effect in spontaneously hypertensive rats. Food
Chem. 118 :96–102.
Li Y, Wang B, Zhang H, Wang Z, Zhu S, Ma H. 2015. High-level expression
of angiotensin converting enzyme inhibitory peptide Tuna AI as tandem
multimer in Escherichia coli BL21 (DE3). Process Biochem.50 :545–552.
http://www.sciencedirect.com/science/article/pii/S1359511315000501.
Lico C, Santi L, Twyman RM, Pezzotti M, Avesani L. 2012. The use of
plants for the production of therapeutic human peptides. Plant
Cell Rep. 31 :439–451.
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, Amann M,
Anderson HR, Andrews KG, Aryee M, Atkinson C, Bacchus LJ, Bahalim AN,
Balakrishnan K, Balmes J, Barker-Collo S, Baxter A, Bell ML, Blore JD,
Blyth F, Bonner C, Borges G, Bourne R, Boussinesq M, Brauer M, Brooks P,
Bruce NG, Brunekreef B, Bryan-Hancock C, Bucello C, Buchbinder R, Bull
F, Burnett RT, Byers TE, Calabria B, Carapetis J, Carnahan E, Chafe Z,
Charlson F, Chen H, Chen JS, Cheng ATA, Child JC, Cohen A, Colson KE,
Cowie BC, Darby S, Darling S, Davis A, Degenhardt L, Dentener F, Des
Jarlais DC, Devries K, Dherani M, Ding EL, Dorsey ER, Driscoll T, Edmond
K, Ali SE, Engell RE, Erwin PJ, Fahimi S, Falder G, Farzadfar F, Ferrari
A, Finucane MM, Flaxman S, Fowkes FGR, Freedman G, Freeman MK, Gakidou
E, Ghosh S, Giovannucci E, Gmel G, Graham K, Grainger R, Grant B,
Gunnell D, Gutierrez HR, Hall W, Hoek HW, Hogan A, Hosgood HD, Hoy D, Hu
H, Hubbell BJ, Hutchings SJ, Ibeanusi SE, Jacklyn GL, Jasrasaria R,
Jonas JB, Kan H, Kanis JA, Kassebaum N, Kawakami N, Khang YH,
Khatibzadeh S, Khoo JP, Kok C, Laden F, Lalloo R, Lan Q, Lathlean T,
Leasher JL, Leigh J, Li Y, Lin JK, Lipshultz SE, London S, Lozano R, Lu
Y, Mak J, Malekzadeh R, Mallinger L, Marcenes W, March L, Marks R,
Martin R, McGale P, McGrath J, Mehta S, Mensah GA, Merriman TR, Micha R,
Michaud C, Mishra V, Hanafiah KM, Mokdad AA, Morawska L, Mozaffarian D,
Murphy T, Naghavi M, Neal B, Nelson PK, Nolla JM, Norman R, Olives C,
Omer SB, Orchard J, Osborne R, Ostro B, Page A, Pandey KD, Parry CDH,
Passmore E, Patra J, Pearce N, Pelizzari PM, Petzold M, Phillips MR,
Pope D, Pope CA, Powles J, Rao M, Razavi H, Rehfuess EA, Rehm JT, Ritz
B, Rivara FP, Roberts T, Robinson C, Rodriguez-Portales JA, Romieu I,
Room R, Rosenfeld LC, Roy A, Rushton L, Salomon JA, Sampson U,
Sanchez-Riera L, Sanman E, Sapkota A, Seedat S, Shi P, Shield K,
Shivakoti R, Singh GM, Sleet DA, Smith E, Smith KR, Stapelberg NJC,
Steenland K, Stöckl H, Stovner LJ, Straif K, Straney L, Thurston GD,
Tran JH, Van Dingenen R, Van Donkelaar A, Veerman JL, Vijayakumar L,
Weintraub R, Weissman MM, White RA, Whiteford H, Wiersma ST, Wilkinson
JD, Williams HC, Williams W, Wilson N, Woolf AD, Yip P, Zielinski JM,
Lopez AD, Murray CJL, Ezzati M. 2012. A comparative risk assessment of
burden of disease and injury attributable to 67 risk factors and risk
factor clusters in 21 regions, 1990-2010: A systematic analysis for the
Global Burden of Disease Study 2010. Lancet380 :2224–2260.
Liu D, Sun H, Zhang L, Li S, Qin Z. 2007. High-Level Expression of
Milk-Derived Antihypertensive Peptide in Escherichia coli and Its
Bioactivity. J. Agric. Food Chem. 55 :5109–5112.
http://dx.doi.org/10.1021/jf0703248.
Lloyd-Jones DM, Levy D. 2013. Epidemiology of Hypertension.Hypertens. A Companion to Braunwald’s Hear. Dis. Second Ed.2 :1–11.
Losacco M, Gallerani R, Gobbetti M, Minervini F, De Leo F. 2007.
Prodution of active angiotensin-I converting enzyme inhibitory peptides
derived from bovine β-casein by recombinant DNA technologies.Biotechnol. J. 2 :1425–1434.
http://dx.doi.org/10.1002/biot.200700092.
Losurdo L, Quintieri L, Caputo L, Gallerani R, Mayo B, De Leo F. 2013.
Cloning and expression of synthetic genes encoding angiotensin-I
converting enzyme (ACE)-inhibitory bioactive peptides in Bifidobacterium
pseudocatenulatum. FEMS Microbiol. Lett. 340 :24–32.
http://femsle.oxfordjournals.org/femsle/340/1/24.full.pdf.
Luna-Suárez S, Medina-Godoy S, Cruz-Hernández A, Paredes-López O. 2010.
Modification of the amaranth 11S globulin storage protein to produce an
inhibitory peptide of the angiotensin I converting enzyme, and its
expression in Escherichia coli. J. Biotechnol.148 :240–247.
http://www.sciencedirect.com/science/article/pii/S0168165610002695.
Lv GS, Huo GC, Fu XY. 2003. Expression of Milk-Derived Antihypertensive
Peptide in Escherichia coli. J. Dairy Sci.86 :1927–1931.
http://www.sciencedirect.com/science/article/pii/S0022030203737795.
Marczak ED, Ohinata K, Lipkowski AW, Yoshikawa M. 2006. Arg-Ile-Tyr
(RIY) derived from rapeseed protein decreases food intake and gastric
emptying after oral administration in mice. Peptides27 :2065–2068.
http://www.sciencedirect.com/science/article/pii/S0196978106001409.
Matoba N, Doyama N, Yamada Y, Maruyama N, Utsumi S, Yoshikawa M. 2001a.
Design and production of genetically modified soybean protein with
anti-hypertensive activity by incorporating potent analogue of
ovokinin(2–7). FEBS Lett. 497 :50–54.
http://www.sciencedirect.com/science/article/pii/S0014579301024346.
Matoba N, Yamada Y, Usui H, Nakagiri R, Yoshikawa M. 2001b. Designing
potent derivatives of ovokinin(2-7), an anti-hypertensive peptide
derived from ovalbumin. Biosci. Biotechnol. Biochem.65 :736–739.
Mayfield SP, Manuell AL, Chen S, Wu J, Tran M, Siefker D, Muto M,
Marin-Navarro J. 2007. Chlamydomonas reinhardtii chloroplasts as protein
factories. Curr. Opin. Biotechnol. 18 :126–133.
Medina-Godoy S, Rodríguez-Yáñez SK, Bobadilla NA, Pérez-Villalva R,
Valdez-Ortiz R, Hong E, Luna-Suárez S, Paredes-López O, Valdez-Ortiz A.
2013. Antihypertensive activity of AMC3, an engineered 11S amaranth
globulin expressed in Escherichia coli, in spontaneously hypertensive
rats. J. Funct. Foods 5 :1441–1449.
http://www.sciencedirect.com/science/article/pii/S1756464613001400.
Michelke L, Deussen A, Kettner K, Dieterich P, Hagemann D, Kriegel TM,
Martin M. 2018. Biotechnological production of the
angiotensin-converting enzyme inhibitory dipeptide
isoleucine-tryptophan. Eng. Life Sci. 18 :218–226.
Miguel M, Recio I, Ramos M, Delgado MA, Aleixandre MA. 2006.
Antihypertensive effect of peptides obtained from Enterococcus
faecalis-fermented milk in rats. J. Dairy Sci.89 :3352–3359.
http://www.sciencedirect.com/science/article/pii/S0022030206723724.
Morales-Camacho JI, Paredes-López O, Espinosa-Hernández E, Fernández
Velasco DA, Luna-Suárez S. 2016. Expression, purification and thermal
stability evaluation of an engineered amaranth protein expressed in
Escherichia coli. Electron. J. Biotechnol. 22 :44–51.
http://www.sciencedirect.com/science/article/pii/S0717345816300264.
Mozafari MR, Khosravi-Darani K, Borazan GG, Cui J, Pardakhty A, Yurdugul
S. 2008. Encapsulation of food ingredients using nanoliposome
technology. Int. J. Food Prop. 11 :833–844.
https://www.tandfonline.com/doi/full/10.1080/10942910701648115.
Murray B, FitzGerald R. 2007. Angiotensin Converting Enzyme Inhibitory
Peptides Derived from Food Proteins: Biochemistry, Bioactivity and
Production. Curr. Pharm. Des. 13 :773–791.
Natesh R, Schwager SLU, Sturrock ED, Acharya KR. 2003. Crystal structure
of the human angiotensin-converting enzyme-lisinopril complex.Nature 421 :551–554.
https://doi.org/10.1038/nature01370.
Nishizawa K, Kita A, Doi C, Yamada Y, Ohinata K, Yoshikawa M, Ishimoto
M. 2008. Accumulation of the bioactive peptides, novokinin, LPYPR and
rubiscolin, in seeds of genetically modified soybean. Biosci.
Biotechnol. Biochem. 72 :3301–3305.
https://www.jstage.jst.go.jp/article/bbb/72/12/72_80468/_pdf.
Norris R, FitzGerald RJ. 2013. Antihypertensive peptides from food
proteins. Bioact. Food Pept. Heal. Dis.http://www.intechopen.com/books/export/citation/EndNote/bioactive-food-peptides-in-health-and-disease/antihypertensive-peptides-from-food-proteins.
Ochoa-Mendez CE, Lara-Hernandez I, Gonzalez LM, Aguirre-Banuelos P,
Ibarra-Barajas M, Castro-Moreno P, Gonzalez-Ortega O, Soria-Guerra RE.
2016. Bioactivity of an antihypertensive peptide expressed in
Chlamydomortas reinhardtii. J. Biotechnol. 240 :76–84.
http://ac.els-cdn.com/S0168165616315905/1-s2.0-S0168165616315905-main.pdf?_tid=a9fa3f72-ec61-11e6-8c63-00000aacb361&acdnat=1486381669_04731dc4c06a041c70d82ed1f530e768.
Oh KS, Park YS, Sung HC. 2002. Expression and purification of an
ACE-inhibitory peptide multimer from synthetic DNA in Escherichia coli.J. Microbiol. Biotechnol. 12 :59–64.
Onishi K, Matoba N, Yamada Y, Doyama N, Maruyama N, Utsumi S, Yoshikawa
M. 2004. Optimal designing of β-conglycinin to genetically incorporate
RPLKPW, a potent anti-hypertensive peptide. Peptides25 :37–43.
http://www.sciencedirect.com/science/article/pii/S0196978103003711.
Oparil S, Zaman MA, Calhoun DA. 2003. Pathogenesis of Hypertension.Ann. Intern. Med. 139 :761–776.
Orona-Tamayo D, Valverde ME, Nieto-Rendón B, Paredes-López O. 2015.
Inhibitory activity of chia (Salvia hispanica L.) protein fractions
against angiotensin I-converting enzyme and antioxidant capacity.LWT - Food Sci. Technol. 64 :236–242.
Park CJ, Lee JH, Hong SS, Lee HS, Kim SC. 1998. High-level expression of
the angiotensin-converting-enzyme-inhibiting peptide, YG-1, as tandem
multimers in Escherichia coli. Appl. Microbiol. Biotechnol.50 :71–76. http://dx.doi.org/10.1007/s002530051258.
Paul M, Teh A, Twyman R, Ma J. 2013. Target Product Selection - Where
Can Molecular Pharming Make the Difference? Curr. Pharm. Des.
Perico N, Ruggenenti P, Remuzzi G. 2017. ACE and SGLT2 inhibitors: the
future for non-diabetic and diabetic proteinuric renal disease.Curr. Opin. Pharmacol. 33 :34–40.
Piepho RW. 2000. Overview of the angiotensin-converting-enzyme
inhibitors. Am. J. Heal. Pharm. 57 :S3-7.
Pihlanto A, Mäkinen S. 2013. Antihypertensive properties of plant
protein derived peptides. Bioact. Food Pept. Heal. Dis.http://www.intechopen.com/books/export/citation/EndNote/bioactive-food-peptides-in-health-and-disease/antihypertensive-properties-of-plant-protein-derived-peptides.
Pires AS, Rosa S, Castanheira S, Fevereiro P, Abranches R. 2012.
Expression of a recombinant human erythropoietin in suspension cell
cultures of Arabidopsis, tobacco and Medicago. Plant Cell. Tissue
Organ Cult. 110 :171–181.
Pooja K, Rani S, Prakash B. 2017. In silico approaches towards the
exploration of rice bran proteins-derived angiotensin-I-converting
enzyme inhibitory peptides. Int. J. Food Prop.20 :2178–2191. https://doi.org/10.1080/10942912.2017.1368552.
Pullalarevu R, Akbar G, Teehan G. 2014. Secondary Hypertension, Issues
in Diagnosis and Treatment. Prim. Care - Clin. Off. Pract.41 :749–764.
Quiros A, Ramos M, Muguerza B, Delgado MA, Miguel M, Aleixandre A, Recio
I. 2007. Identification of novel antihypertensive peptides in milk
fermented with Enterococcus faecalis. Int. Dairy J.17 :33–41.
Rao SQ, Su YJ, Li JH, Xu ZZ, Yang YJ. 2009. Design and Expression of
Recombinant Antihypertensive Peptide Multimer Gene in Escherichia coli
BL21. J. Microbiol. Biotechnol. 19 :1620–1627.
Rao SQ, Zang XY, Yang ZQ, Gao L, Yin YQ, Fang WM. 2016. Soluble
expression and purification of the recombinant bioactive peptide
precursor BPP-1 in Escherichia coli using a cELP-SUMO dual fusion
system. Protein Expr. Purif. 118 :113–119.
http://ac.els-cdn.com/S1046592815300978/1-s2.0-S1046592815300978-main.pdf?_tid=c64c1932-1c43-11e6-b14f-00000aacb360&acdnat=1463498990_c56f26b96fca15b3535af97d2b0a7125.
Rayaprolu S, Hettiarachchy N, Horax R, Satchithanandam E, Chen P,
Mauromoustakos A. 2015. Amino Acid Profiles of 44 Soybean Lines and
ACE-I Inhibitory Activities of Peptide Fractions from Selected Lines.J. Am. Oil Chem. Soc. 92 :1023–1033.
http://download.springer.com/static/pdf/189/art%253A10.1007%252Fs11746-015-2655-y.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs11746-015-2655-y&token2=exp=1455304249~acl=%2Fstatic%2Fpdf%2F189%2Fart%25253A10.1007%25252Fs11746-015-265.
Renye JA, Somkuti GA. 2008. Cloning of milk-derived bioactive peptides
in Streptococcus thermophilus. Biotechnol. Lett.30 :723–730.
http://download.springer.com/static/pdf/609/art%253A10.1007%252Fs10529-007-9600-6.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs10529-007-9600-6&token2=exp=1450235258~acl=%2Fstatic%2Fpdf%2F609%2Fart%25253A10.1007%25252Fs10529-007-960.
Renye JA, Somkuti GA. 2015. Nisin-induced expression of a recombinant
antihypertensive peptide in dairy lactic acid bacteria.Biotechnol. Lett. 37 :1447–1454.
Richard MA, Huan T, Ligthart S, Gondalia R, Jhun MA, Brody JA, Irvin MR,
Marioni R, Shen J, Tsai PC, Montasser ME, Jia Y, Syme C, Salfati EL,
Boerwinkle E, Guan W, Mosley TH, Bressler J, Morrison AC, Liu C,
Mendelson MM, Uitterlinden AG, van Meurs JB, Heijmans BT, ’t Hoen PAC,
van Meurs J, Isaacs A, Jansen R, Franke L, Boomsma DI, Pool R, van
Dongen J, Hottenga JJ, van Greevenbroek MMJ, Stehouwer CDA, van der
Kallen CJH, Schalkwijk CG, Wijmenga C, Zhernakova A, Tigchelaar EF,
Slagboom PE, Beekman M, Deelen J, van Heemst D, Veldink JH, van den Berg
LH, van Duijn CM, Hofman A, Uitterlinden AG, Jhamai PM, Verbiest M,
Suchiman HED, Verkerk M, van der Breggen R, van Rooij J, Lakenberg N,
Mei H, van Iterson M, van Galen M, Bot J, van ’t Hof P, Deelen P, Nooren
I, Moed M, Vermaat M, Zhernakova D V., Luijk R, Bonder MJ, van Dijk F,
Arindrarto W, Kielbasa SM, Swertz MA, van Zwet EW, Franco OH, Zhang G,
Li Y, Stewart JD, Bis JC, Psaty BM, Chen YDI, Kardia SLR, Zhao W, Turner
ST, Absher D, Aslibekyan S, Starr JM, McRae AF, Hou L, Just AC, Schwartz
JD, Vokonas PS, Menni C, Spector TD, Shuldiner A, Damcott CM, Rotter JI,
Palmas W, Liu Y, Paus T, Horvath S, O’Connell JR, Guo X, Pausova Z,
Assimes TL, Sotoodehnia N, Smith JA, Arnett DK, Deary IJ, Baccarelli AA,
Bell JT, Whitsel E, Dehghan A, Levy D, Fornage M. 2017. DNA Methylation
Analysis Identifies Loci for Blood Pressure Regulation. Am. J.
Hum. Genet. 101 :888–902.
Rimoldi SF, Scherrer U, Messerli FH. 2014. Secondary arterial
hypertension: When, who, and how to screen? Eur. Heart J.35 :1245–1254.
Rojas-Ronquillo R, Cruz-Guerrero A, Flores-Najera A, Rodriguez-Serrano
G, Gomez-Ruiz L, Reyes-Grajeda JP, Jimenez-Guzman J, Garcia-Garibay M.
2012. Antithrombotic and angiotensin-converting enzyme inhibitory
properties of peptides released from bovine casein by Lactobacillus
casei Shirota. Int. Dairy J. 26 :147–154.
Rosales-Mendoza S, Paz-Maldonado LMT, Govea-Alonso DO, Korban SS. 2013.
Engineering production of antihypertensive peptides in plants.Plant Cell Tissue Organ Cult. 112 :159–169.
Ruiz-Gimenez P, Salom JB, Marcos JF, Valles S, Martinez-Maqueda D, Recio
I, Torregrosa G, Alborch E, Manzanares P. 2012. Antihypertensive effect
of a bovine lactoferrin pepsin hydrolysate: Identification of novel
active peptides. Food Chem. 131 :266–273.
Ryan JT, Ross RP, Bolton D, Fitzgerald GF, Stanton C. 2011. Bioactive
peptides from muscle sources: Meat and fish. Nutrients3 :765–791.
Santos-Ballardo D, Germán-Báez L, Cruz-Mendívil A, Fuentes-Gutiérrez C,
Milán-Carrillo J, Reyes-Moreno C, Valdez-Ortiz A. 2013. Expression of
the acidic-subunit of amarantin, carrying the antihypertensive
biopeptides VY, in cell suspension cultures of Nicotiana tabacum NT1.Plant Cell, Tissue Organ Cult. 113 :315–322.
http://dx.doi.org/10.1007/s11240-012-0271-1.
Schillberg S, Raven N, Fischer R, Twyman R, Schiermeyer A. 2013.
Molecular Farming of Pharmaceutical Proteins Using Plant Suspension Cell
and Tissue Cultures. Curr. Pharm. Des.
Seppo L, Jauhiainen T, Poussa T, Korpela R. 2003. A fermented milk high
in bioactive peptides has a blood pressure-lowering effect in
hypertensive subjects. Am. J. Clin. Nutr. 77 :326–330.
Shen W, Matsui T. 2017. Current knowledge of intestinal absorption of
bioactive peptides. Food Funct. 8 :4306–4314.
da Silva Malheiros P, Daroit DJ, Brandelli A. 2010. Food applications of
liposome-encapsulated antimicrobial peptides. Trends Food Sci.
Technol. 21 :284–292.
Soares de Castro RJ, Sato HH. 2015. Biologically active peptides:
Processes for their generation, purification and identification and
applications as natural additives in the food and pharmaceutical
industries. Food Res. Int. 74 :185–198.
Spök A, Twyman RM, Fischer R, Ma JKC, Sparrow PAC. 2008. Evolution of a
regulatory framework for pharmaceuticals derived from genetically
modified plants. Trends Biotechnol. 26 :506–517.
Sun H, Chang Q, Liu L, Chai K, Lin G, Huo Q, Zhao Z, Zhao Z. 2017.
High-Throughput and Rapid Screening of Novel ACE Inhibitory Peptides
from Sericin Source and Inhibition Mechanism by Using in Silico and in
Vitro Prescriptions. J. Agric. Food Chem.65 :10020–10028.
Tai HM, Li CC, Hung CY, Yin LJ. 2018. Production of functional peptides
with inhibition ability against angiotensin I-Converting enzyme using P.
pastoris expression system. J. Food Drug Anal.26 :1097–1104. https://doi.org/10.1016/j.jfda.2018.02.001.
Taladrid D, Marín D, Alemán A, Álvarez-Acero I, Montero P, Gómez-Guillén
MC. 2017. Effect of chemical composition and sonication procedure on
properties of food-grade soy lecithin liposomes with added glycerol.Food Res. Int. 100 :541–550.
Tran HB, Yamamoto A, Matsumoto S, Ito H, Igami K, Miyazaki T, Kondo R,
Shimizu K. 2014. Hypotensive effects and angiotensin-converting enzyme
inhibitory peptides of reishi (Ganoderma lingzhi) auto-digested extract.Molecules 19 :13473–13485.
http://www.ncbi.nlm.nih.gov/pubmed/25178067.
Twyman RM, Stoger E, Schillberg S, Christou P, Fischer R. 2003.
Molecular farming in plants: Host systems and expression technology.Trends Biotechnol. 21 :570–578.
Vásquez-Villanueva R, Marina ML, García MC. 2015. Revalorization of a
peach (Prunus persica (L.) Batsch) byproduct: Extraction and
characterization of ACE-inhibitory peptides from peach stones. J.
Funct. Foods 18 :137–146.
Wakasa Y, Zhao H, Hirose S, Yamauchi D, Yamada Y, Yang L, Ohinata K,
Yoshikawa M, Takaiwa F. 2011. Antihypertensive activity of transgenic
rice seed containing an 18-repeat novokinin peptide localized in the
nucleolus of endosperm cells. Plant Biotechnol. J.9 :729–735. http://dx.doi.org/10.1111/j.1467-7652.2010.00576.x.
Wang NY, Young JH, Meoni LA, Ford DE, Erlinger TP, Klag MJ. 2008. Blood
pressure change and risk of hypertension associated with parental
hypertension: The Johns Hopkins precursors study. Arch. Intern.
Med. 168 :643–648.
Wang XL, Ma SN, Yuan YH, Ding Y, Li DS. 2015. Expression and
purification recombinant antihypertensive peptide ameliorates
hypertension in rats with spontaneous hypertension. Protein Expr.
Purif. 113 :30–34.
http://www.sciencedirect.com/science/article/pii/S1046592815001011.
Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I,
Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N,
Marten J, Karaman I, Segura Lepe MP, O’Reilly PF, Knight J, Snieder H,
Kato N, He J, Shyong Tai E, Abdullah Said M, Porteous D, Alver M,
Poulter N, Farrall M, Gansevoort RT, Padmanabhan S, Mägi R, Stanton A,
Connell J, Bakker SJL, Metspalu A, Shields DC, Thom S, Brown M, Sever P,
Esko T, Hayward C, van der Harst P, Saleheen D, Chowdhury R, Chambers
JC, Chasman DI, Chakravarti A, Newton-Cheh C, Lindgren CM, Levy D,
Kooner JS, Keavney B, Tomaszewski M, Samani NJ, Howson JMM, Tobin MD,
Munroe PB, Ehret GB, Wain L V., Barnes MR, Tzoulaki I, Caulfield MJ,
Elliott P, Wain V, Vaez A, Jansen R, Joehanes R, van der Most PJ, Mesut
Erzurumluoglu A, O’Reilly P, Rose LM, Verwoert GC, Hottenga JJ,
Strawbridge RJ, Esko T, Arking DE, Hwang SJ, Guo X, Kutalik Z, Trompet
S, Shrine N, Teumer A, Ried JS, Bis JC, Smith A V., Amin N, Nolte IM,
Lyytikäinen LP, Mahajan A, Wareham NJ, Hofer E, Joshi PK, Kristiansson
K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sõber S, Vuckovic D, Luan
J, Fabiola Del Greco M, Ayers KL, Marrugat J, Ruggiero D, Lopez LM,
Niiranen T, Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang W, Gandin
I, Harris SE, Zemonik T, Lu Y, Shah N, de Borst MH, Mangino M, Prins BP,
Campbell A, Li-Gao R, Chauhan G, Oldmeadow C, Abecasis G, Abedi M,
Barbieri CM, Batini C, Blake T, Boehnke M, Bottinger EP, Braund PS,
Brumat M, Campbell H, Cocca M, Collins F, Cordell HJ, Damman JJ, Davies
G, de Geus EJ, de Mutsert R, Deelen J, Demirkale Y, Doney ASF, Dörr M,
Ferreira T, Frånberg M, Giedraitis V, Gieger C, Giulianini F, Gow AJ,
Hamsten A, Harris TB, Hofman A, Holliday EG, Jarvelin MR, Johansson Å,
Johnson AD, Jousilahti P, Jula A, Kähönen M, Kathiresan S, Khaw KT,
Kolcic I, Koskinen S, Langenberg C, Larson M, Launer LJ, Lehne B,
Liewald DCM, Lin L, Lind L, Mach F, Mamasoula C, Menni C, Milaneschi Y,
Morgan A, Morris AD, Morrison AC, Munson PJ, Nandakumar P, Nguyen QT,
Nutile T, Oldehinkel AJ, Oostra BA, Org E, Palotie A, Paré G, Pattie A,
Penninx BWJH, Pramstaller PP, Raitakari OT, Rice K, Ridker PM, Riese H,
Ripatti S, Robino A, Rotter JI, Rudan I, Saba Y, Saint Pierre A, Sala
CF, Sarin AP, Schmidt R, Scott R, Seelen MA, Siscovick D, Sorice R,
Stott DJ, Sundström J, Swertz M, Taylor KD, Tzourio C, Uitterlinden AG,
Völker U, Vollenweider P, Wild S, Willemsen G, Wright AF, Yao J,
Thériault S, Conen D, John A, Debette S, Mook-Kanamori DO, Zeggini E,
Spector TD, Palmer CNA, Vergnaud AC, Loos RJF, Polasek O, Starr JM,
Girotto G, Lindgren CM, Vitart V, Tuomilehto J, Gyllensten U, Knekt P,
Deary IJ, Ciullo M, Elosua R, Keavney BD, Hicks AA, Scott RA, Gasparini
P, Laan M, Liu YM, Watkins H, Hartman CA, Salomaa V, Toniolo D, Perola
M, Wilson JF, Schmidt H, Zhao JH, Lehtimäki T, van Duijn CM, Gudnason V,
Psaty BM, Peters A, Rettig R, James A, Wouter Jukema J, Strachan DP,
Palmas W, Ingelsson E, Boomsma DI, Franco OH, Bochud M, Morris AP. 2017.
Genome-wide association analysis identifies novel blood pressure loci
and offers biological insights into cardiovascular risk. Nat.
Genet. 49 :403–415.
Weber MA. 1991. Overview of Fosinopril: A Novel ACE Inhibitor.Drug Investig. 3 :3–11.
Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, Clement
DL, Coca A, De Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J,
Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip
GYH, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E,
Tsioufis C, Aboyans V, Desormais I, De Backer G, Heagerty AM, Agewall S,
Bochud M, Borghi C, Boutouyrie P, Brguljan J, Bueno H, Caiani EG,
Carlberg B, Chapman N, Cífková R, Cleland JGF, Collet JP, Coman IM, De
Leeuw PW, Delgado V, Dendale P, Diener HC, Dorobantu M, Fagard R,
Farsang C, Ferrini M, Graham IM, Grassi G, Haller H, Hobbs FDR,
Jelakovic B, Jennings C, Katus HA, Kroon AA, Leclercq C, Lovic D, Lurbe
E, Manolis AJ, McDonagh TA, Messerli F, Muiesan ML, Nixdorff U, Olsen
MH, Parati G, Perk J, Piepoli MF, Polonia J, Ponikowski P, Richter DJ,
Rimoldi SF, Roffi M, Sattar N, Seferovic PM, Simpson IA, Sousa-Uva M,
Stanton A V., Van De Borne P, Vardas P, Volpe M, Wassmann S, Windecker
S, Zamorano JL. 2018. 2018 ESC/ESH Guidelines for themanagement of
arterial hypertension. Eur. Heart J. 39 :3021–3104.
https://doi.org/10.1093/eurheartj/ehy339.
World Health Organization. 2013. A global brief on Hypertension - World
Health Day 2013. World Heal. Organ. Geneva, World Health
Organization 1–40 p.
Wu J, Aluko RE, Nakai S. 2006. Structural Requirements of Angiotensin
I-Converting Enzyme Inhibitory Peptides: Quantitative
Structure−Activity Relationship Study of Di- and Tripeptides. J.
Agric. Food Chem. 54 :732–738.
Wu J, Liao W, Udenigwe CC. 2017. Revisiting the mechanisms of ACE
inhibitory peptides from food proteins. Trends Food Sci. Technol.69 :214–219.
Wu Q, Du J, Jia J, Kuang C. 2016. Production of ACE inhibitory peptides
from sweet sorghum grain protein using alcalase: Hydrolysis kinetic,
purification and molecular docking study. Food Chem.199 :140–149.
http://ac.els-cdn.com/S0308814615302909/1-s2.0-S0308814615302909-main.pdf?_tid=cfd75606-1c43-11e6-bfba-00000aab0f01&acdnat=1463499005_23eac51ea42ac2856762f238dbb0352b.
Xie C liang, Choung S young, Cao G ping, Lee KW, Choi YJ. 2015. In
silico investigation of action mechanism of four novel angiotensin-I
converting enzyme inhibitory peptides modified with Trp. J. Funct.
Foods 17 :632–639.
Yamada Y, Nishizawa K, Yokoo M, Zhao H, Onishi K, Teraishi M, Utsumi S,
Ishimoto M, Yoshikawa M. 2008. Anti-hypertensive activity of genetically
modified soybean seeds accumulating novokinin. Peptides29 :331–337.
Yang L, Tada Y, Yamamoto MP, Zhao H, Yoshikawa M, Takaiwa F. 2006. A
transgenic rice seed accumulating an anti-hypertensive peptide reduces
the blood pressure of spontaneously hypertensive rats. FEBS Lett.580 :3315–3320.
http://www.sciencedirect.com/science/article/pii/S0014579306005746.
Yeates K, Lohfeld L, Sleeth J, Morales F, Rajkotia Y, Ogedegbe O. 2015.
A Global Perspective on Cardiovascular Disease in Vulnerable
Populations. Can. J. Cardiol. 31 :1081–1093.
Yu Z, Yin Y, Zhao W, Yu Y, Liu B, Liu J, Chen F. 2011. Novel peptides
derived from egg white protein inhibiting alpha-glucosidase. Food
Chem. 129 :1376–1382.
http://www.sciencedirect.com/science/article/pii/S0308814611007709.
Zisaki A, Miskovic L, Hatzimanikatis V. 2014. Antihypertensive Drugs
Metabolism: An Update to Pharmacokinetic Profiles and Computational
Approaches. Curr. Pharm. Des. 21 :806–822.