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Association of Patent Ductus Arteriosus with extubation failure among preterm infants
  • +5
  • Dhruv Gupta,
  • Rachel Greenberg,
  • Girija Natarajan,
  • Sanket Jani,
  • Amit Sharma,
  • Michael Cotten,
  • Ronald Thomas,
  • Sanjay Chawla
Dhruv Gupta
Maternal Fetal Medicine of Southwest Florida

Corresponding Author:[email protected]

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Rachel Greenberg
Duke University Department of Pediatrics
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Girija Natarajan
Central Michigan University
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Sanket Jani
Central Michigan University
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Amit Sharma
Central Michigan University
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Michael Cotten
Duke University Department of Pediatrics
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Ronald Thomas
Central Michigan University
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Sanjay Chawla
Central Michigan University
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Abstract

Backround: Mechanical ventilation is associated with mortality/morbidities in preterm infants. Nearly a third of these infants fail extubation and this may increase morbidities. Objective: To evaluate the association of symptomatic patent ductus arteriosus with failure of extubation among preterm infants. Methods: This was a retrospective study on preterm infants (birth weight <1,250 grams and gestational age ≥23weeks) born between January 2009 and December 2016, who were mechanically ventilated and extubated within the first 60 days of age. Results: 360 infants were evaluated, of these, 26% failed and 74% succeeded the initial extubation attempt. On adjusted analysis, symptomatic ductus was associated with an increased risk of extubation failure. Conclusion(s): Presence of symptomatic patent ductus arteriosus was associated with extubation failure. Further investigations are needed to establish whether screening for presence of ductus and treatment of the same, prior to extubation among these infants, improves chances of successful extubation and cardiorespiratory outcomes.
05 Oct 2022Submitted to Pediatric Pulmonology
05 Oct 2022Submission Checks Completed
05 Oct 2022Assigned to Editor
10 Oct 2022Reviewer(s) Assigned
18 Nov 2022Review(s) Completed, Editorial Evaluation Pending
20 Nov 2022Editorial Decision: Revise Major
30 Jan 20231st Revision Received
30 Jan 2023Assigned to Editor
30 Jan 2023Submission Checks Completed
30 Jan 2023Review(s) Completed, Editorial Evaluation Pending
30 Jan 2023Reviewer(s) Assigned
17 Feb 2023Editorial Decision: Revise Minor
06 Mar 20232nd Revision Received
07 Mar 2023Submission Checks Completed
07 Mar 2023Assigned to Editor
07 Mar 2023Review(s) Completed, Editorial Evaluation Pending
07 Mar 2023Reviewer(s) Assigned
11 Apr 2023Editorial Decision: Accept